Synthesis and antinociceptive activity of 9-phenyl-oxy or 9-acyl-oxy derivatives of xanthene, thioxanthene and acridine
The synthesis of 9-alkyl-oxy or 9-acyl-oxy derivatives of xanthene, thioxanthene and acridine is reported. A potent antinociceptive activity was confirmed for the 9-phenyl-9-propionyl-oxy derivative bearing an oxygen or sulfur atom in the heteroaromatic structure. Synthèse de dérivés phényl-9-alkoxy...
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| Veröffentlicht in: | European journal of medicinal chemistry 1989, Vol.24 (4), p.391-396 |
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| container_end_page | 396 |
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| container_issue | 4 |
| container_start_page | 391 |
| container_title | European journal of medicinal chemistry |
| container_volume | 24 |
| creator | Llama, Emilio F del Campo, Carmen Capo, Miguel Anadon, Maria |
| description | The synthesis of 9-alkyl-oxy or 9-acyl-oxy derivatives of xanthene, thioxanthene and acridine is reported. A potent antinociceptive activity was confirmed for the 9-phenyl-9-propionyl-oxy derivative bearing an oxygen or sulfur atom in the heteroaromatic structure.
Synthèse de dérivés phényl-9-alkoxy-9 ou acyl-oxy-9 du xanthène, thioxanthène et de l'acridine. Une forte activité antinociceptive se manifeste lorsque le dérivé phényl-9-propionyl-oxy-9, porte un oxygène ou un soufre dans la structure hétéroaromatique. |
| doi_str_mv | 10.1016/0223-5234(89)90083-4 |
| format | Article |
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Synthèse de dérivés phényl-9-alkoxy-9 ou acyl-oxy-9 du xanthène, thioxanthène et de l'acridine. Une forte activité antinociceptive se manifeste lorsque le dérivé phényl-9-propionyl-oxy-9, porte un oxygène ou un soufre dans la structure hétéroaromatique.</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/0223-5234(89)90083-4</identifier><identifier>CODEN: EJMCA5</identifier><language>eng</language><publisher>Oxford: Elsevier Masson SAS</publisher><subject>acridine derivatives ; antinociceptive activity ; Chemistry ; Exact sciences and technology ; Heterocyclic compounds ; Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives ; Organic chemistry ; Preparations and properties ; thioxanthene derivatives ; trimeperidine analogues ; xanthene derivatives</subject><ispartof>European journal of medicinal chemistry, 1989, Vol.24 (4), p.391-396</ispartof><rights>1989</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0223-5234(89)90083-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,4023,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19490776$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Llama, Emilio F</creatorcontrib><creatorcontrib>del Campo, Carmen</creatorcontrib><creatorcontrib>Capo, Miguel</creatorcontrib><creatorcontrib>Anadon, Maria</creatorcontrib><title>Synthesis and antinociceptive activity of 9-phenyl-oxy or 9-acyl-oxy derivatives of xanthene, thioxanthene and acridine</title><title>European journal of medicinal chemistry</title><description>The synthesis of 9-alkyl-oxy or 9-acyl-oxy derivatives of xanthene, thioxanthene and acridine is reported. A potent antinociceptive activity was confirmed for the 9-phenyl-9-propionyl-oxy derivative bearing an oxygen or sulfur atom in the heteroaromatic structure.
Synthèse de dérivés phényl-9-alkoxy-9 ou acyl-oxy-9 du xanthène, thioxanthène et de l'acridine. Une forte activité antinociceptive se manifeste lorsque le dérivé phényl-9-propionyl-oxy-9, porte un oxygène ou un soufre dans la structure hétéroaromatique.</description><subject>acridine derivatives</subject><subject>antinociceptive activity</subject><subject>Chemistry</subject><subject>Exact sciences and technology</subject><subject>Heterocyclic compounds</subject><subject>Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives</subject><subject>Organic chemistry</subject><subject>Preparations and properties</subject><subject>thioxanthene derivatives</subject><subject>trimeperidine analogues</subject><subject>xanthene derivatives</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNo9kE9LxDAQxYMouK5-Aw-9CApGkyZpk4sgi_9gwYN6DmkyZSNrWpKwbr-9rbt6GB4P3sw8fgidU3JDCa1uSVkyLErGL6W6UoRIhvkBmtG6kpiVgh-i2X_kGJ2k9EkIERUhM_T9NoS8guRTYYIbJ_vQWW-hz34DhbGj-DwUXVso3K8gDGvcbUcfR2_s3jmIfmOmjTQlt2a6GeC6yCvf_bndAxu98wFO0VFr1gnO9jpHH48P74tnvHx9elncLzGUTGasGLNmbFrz1rracNsYCpQpXnMQwlaClrUSpRSuaZQA5XjDnKJCKelAMsLm6GJ3tzfJmnUbTbA-6T76LxMHTRVXpK6rMXe3y8FYZuMh6mQ9BAvOR7BZu85rSvSEW08s9cRSS6V_cWvOfgBFEXTb</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Llama, Emilio F</creator><creator>del Campo, Carmen</creator><creator>Capo, Miguel</creator><creator>Anadon, Maria</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>IQODW</scope></search><sort><creationdate>1989</creationdate><title>Synthesis and antinociceptive activity of 9-phenyl-oxy or 9-acyl-oxy derivatives of xanthene, thioxanthene and acridine</title><author>Llama, Emilio F ; del Campo, Carmen ; Capo, Miguel ; Anadon, Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e238t-933ca56074fcd7a4cba1e139474e55c6512795285dbb95e9d4b3d915998de8303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>acridine derivatives</topic><topic>antinociceptive activity</topic><topic>Chemistry</topic><topic>Exact sciences and technology</topic><topic>Heterocyclic compounds</topic><topic>Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives</topic><topic>Organic chemistry</topic><topic>Preparations and properties</topic><topic>thioxanthene derivatives</topic><topic>trimeperidine analogues</topic><topic>xanthene derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Llama, Emilio F</creatorcontrib><creatorcontrib>del Campo, Carmen</creatorcontrib><creatorcontrib>Capo, Miguel</creatorcontrib><creatorcontrib>Anadon, Maria</creatorcontrib><collection>Pascal-Francis</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Llama, Emilio F</au><au>del Campo, Carmen</au><au>Capo, Miguel</au><au>Anadon, Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and antinociceptive activity of 9-phenyl-oxy or 9-acyl-oxy derivatives of xanthene, thioxanthene and acridine</atitle><jtitle>European journal of medicinal chemistry</jtitle><date>1989</date><risdate>1989</risdate><volume>24</volume><issue>4</issue><spage>391</spage><epage>396</epage><pages>391-396</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><coden>EJMCA5</coden><abstract>The synthesis of 9-alkyl-oxy or 9-acyl-oxy derivatives of xanthene, thioxanthene and acridine is reported. A potent antinociceptive activity was confirmed for the 9-phenyl-9-propionyl-oxy derivative bearing an oxygen or sulfur atom in the heteroaromatic structure.
Synthèse de dérivés phényl-9-alkoxy-9 ou acyl-oxy-9 du xanthène, thioxanthène et de l'acridine. Une forte activité antinociceptive se manifeste lorsque le dérivé phényl-9-propionyl-oxy-9, porte un oxygène ou un soufre dans la structure hétéroaromatique.</abstract><cop>Oxford</cop><pub>Elsevier Masson SAS</pub><doi>10.1016/0223-5234(89)90083-4</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0223-5234 |
| ispartof | European journal of medicinal chemistry, 1989, Vol.24 (4), p.391-396 |
| issn | 0223-5234 1768-3254 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_19490776 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings |
| subjects | acridine derivatives antinociceptive activity Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Organic chemistry Preparations and properties thioxanthene derivatives trimeperidine analogues xanthene derivatives |
| title | Synthesis and antinociceptive activity of 9-phenyl-oxy or 9-acyl-oxy derivatives of xanthene, thioxanthene and acridine |
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