Synthesis and antinociceptive activity of 9-phenyl-oxy or 9-acyl-oxy derivatives of xanthene, thioxanthene and acridine

The synthesis of 9-alkyl-oxy or 9-acyl-oxy derivatives of xanthene, thioxanthene and acridine is reported. A potent antinociceptive activity was confirmed for the 9-phenyl-9-propionyl-oxy derivative bearing an oxygen or sulfur atom in the heteroaromatic structure. Synthèse de dérivés phényl-9-alkoxy...

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Veröffentlicht in:	European journal of medicinal chemistry 1989, Vol.24 (4), p.391-396
Hauptverfasser:	Llama, Emilio F, del Campo, Carmen, Capo, Miguel, Anadon, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	acridine derivatives antinociceptive activity Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Organic chemistry Preparations and properties thioxanthene derivatives trimeperidine analogues xanthene derivatives
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Zusammenfassung:	The synthesis of 9-alkyl-oxy or 9-acyl-oxy derivatives of xanthene, thioxanthene and acridine is reported. A potent antinociceptive activity was confirmed for the 9-phenyl-9-propionyl-oxy derivative bearing an oxygen or sulfur atom in the heteroaromatic structure. Synthèse de dérivés phényl-9-alkoxy-9 ou acyl-oxy-9 du xanthène, thioxanthène et de l'acridine. Une forte activité antinociceptive se manifeste lorsque le dérivé phényl-9-propionyl-oxy-9, porte un oxygène ou un soufre dans la structure hétéroaromatique.
ISSN:	0223-5234 1768-3254
DOI:	10.1016/0223-5234(89)90083-4