Differential regulation of enteric and systemic salmonellosis by slyA

Mutation of slyA, which reduces Salmonella typhimurium virulence in mice, caused only minor attenuation of S. typhimurium virulence in orally inoculated calves. This correlated with modest reductions in intestinal invasion and enteropathogenic responses in bovine ligated ileal loops. slyA appears to...

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Veröffentlicht in:	Infection and Immunity 1999-09, Vol.67 (9), p.4950-4954
Hauptverfasser:	Watson, P.R, Paulin, S.M, Bland, A.P, Libby, S.J, Jones, P.W, Wallis, T.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial diseases Bacterial Proteins Bacterial Toxins - genetics Bacteriology Biological and medical sciences Cattle Experimental bacterial diseases and models experimental infections Fundamental and applied biological sciences. Psychology Genetics Hemolysin Proteins - genetics ileum Infectious diseases Intestinal Mucosa - pathology intestines Medical sciences Microbiology Molecular and Cellular Pathogenesis oral administration regulator genes Salmonella Infections, Animal - pathology Salmonella typhimurium Salmonella typhimurium - genetics Salmonella typhimurium - isolation & purification Salmonella typhimurium - pathogenicity Transcription Factors Virulence
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Beschreibung
Zusammenfassung:	Mutation of slyA, which reduces Salmonella typhimurium virulence in mice, caused only minor attenuation of S. typhimurium virulence in orally inoculated calves. This correlated with modest reductions in intestinal invasion and enteropathogenic responses in bovine ligated ileal loops. slyA appears to regulate virulence genes involved in systemic, but not enteric, salmonellosis.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.67.9.4950-4954.1999