Glycosaminoglycans in patellar cartilage

We obtained samples of patellar cartilage at the time of surgery from 20 patients: 11 with normal and 9 with macroscopic cartilaginous degeneration. The glycosaminoglycans were separated by cellulose acetateelectrophoresis, and the relative content of major glycosaminoglycans was measured by optic s...

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Veröffentlicht in:	Acta orthopaedica 1989, Vol.60 (1), p.23-25
Hauptverfasser:	Olsen, Elith Bjarne, Trier, Klaus, Mailer, Henrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Cartilage Diseases - metabolism Cartilage, Articular - analysis Child Chondroitin Sulfates - analysis Dermatan Sulfate - analysis Electrophoresis, Cellulose Acetate Female Glycosaminoglycans - analysis Humans Hyaluronic Acid - analysis Investigative techniques, diagnostic techniques (general aspects) Keratan Sulfate - analysis Male Medical sciences Middle Aged Osteoarticular system. Muscles Patella Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Uronic Acids - analysis
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Zusammenfassung:	We obtained samples of patellar cartilage at the time of surgery from 20 patients: 11 with normal and 9 with macroscopic cartilaginous degeneration. The glycosaminoglycans were separated by cellulose acetateelectrophoresis, and the relative content of major glycosaminoglycans was measured by optic scanning. The total content of glycosaminoglycans was estimated by uronic acid analysis. We found that degenerated cartilage contained an increase in dermatan sulfate and hyaluronic acid and a decrease in chondroitin 6-sulfate and total uronic acid concentration, with only slight changes in chondroitin 4-sulfate and keratan sulfate compared with normal cartilage.
ISSN:	1745-3674 0001-6470 1745-3682
DOI:	10.3109/17453678909150084