Carvastatin suppresses intimal thickening of rabbit carotid artery after balloon catheter injury probably through the inhibition of vascular smooth muscle cell proliferation and migration

In order to test whether a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor has an anti-atherogenic activity, the effects of carvastatin, a newly developed potent inhibitor, and pravastatin were examined on the intimal thickening of the artery after the endothelial denudation indu...

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Veröffentlicht in:	Scandinavian journal of clinical and laboratory investigation 1999, Vol.59 (3), p.159-166
1. Verfasser:	M Komukai, Y Saitoh-Wajima, J Tashiro, M Shinomiya, Y Saito, N Morisaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticoagulants - pharmacology Arteriosclerosis - drug therapy Arteriosclerosis - pathology Becaplermin Biological and medical sciences Carcinoma, Hepatocellular Carotid Arteries - drug effects Carotid Arteries - pathology Catheterization - adverse effects Cell Division - drug effects Cell Movement - drug effects Cholesterol, LDL - biosynthesis General and cellular metabolism. Vitamins Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Male Medical sciences Mevalonic Acid - pharmacology Muscle, Smooth, Vascular - chemistry Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Naphthalenes - chemistry Naphthalenes - pharmacology Pharmacology. Drug treatments Platelet-Derived Growth Factor - pharmacology Pravastatin - pharmacology Proto-Oncogene Proteins c-sis Pyrans - chemistry Pyrans - pharmacology Rabbits Receptors, LDL - biosynthesis Tumor Cells, Cultured Tunica Intima - drug effects
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Zusammenfassung:	In order to test whether a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor has an anti-atherogenic activity, the effects of carvastatin, a newly developed potent inhibitor, and pravastatin were examined on the intimal thickening of the artery after the endothelial denudation induced by balloon catheter injury. Rabbits were divided into four groups; control, pravastatin-treated (20 mg kg-1 day-1) and two of carvastatin-treated groups (10 or 20 mg kg-1 day-1
ISSN:	0036-5513 1502-7686
DOI:	10.1080/00365519950185689