Effects of vagotomy on cardiovascular response to periodic apneas in sedated pigs

Effects of vagotomy on cardiovascular response to periodic apneas in sedated pigs

Pulmonary and Critical Care Division, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11042 There are few studies investigating the influence of vagally mediated reflexes on the cardiovascular response to apneas. In 12 sedate...

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Veröffentlicht in:Journal of applied physiology (1985) 1999-06, Vol.86 (6), p.1890-1896
Hauptverfasser: Slamowitz, D, Chen, L, Scharf, S. M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Apnea - physiopathology
Biological and medical sciences
Blood Gas Analysis
Blood Pressure - physiology
Cardiac Output - physiology
Circulatory system
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Female
Heart Rate - physiology
Hemodynamics - physiology
Hogs
Hypnotics and Sedatives - pharmacology
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Respiration, Artificial
Sleep disorders
Stroke Volume - physiology
Swine
Vagotomy
Vascular Resistance - physiology
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Zusammenfassung:Pulmonary and Critical Care Division, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11042 There are few studies investigating the influence of vagally mediated reflexes on the cardiovascular response to apneas. In 12 sedated preinstrumented pigs, we studied the effects of vagotomy during apneas, controlling for apnea periodicity and thoracic mechanical effects. Nonobstructive apneas were produced by paralyzing and mechanically ventilating the animals, then turning the ventilator off and on every 30 s. Before vagotomy, relative to baseline, apnea caused increased mean arterial pressure (MAP; +19 ± 25%, P  
ISSN:8750-7587
1522-1601
DOI:10.1152/jappl.1999.86.6.1890