Tri-n-octyl[32P]phosphine oxide. synthesis and biodistribution via the hepatic artery of rats

The purpose of this study was to analyse the biodistribution of tri‐n‐octyl[32P]phosphine oxide ([32P]TOPO) in rats following intrahepatic arterial injection so as to assess its potential as a radiopharmaceutical for the treatment of hepatic tumours in humans. The retention of [32P]TOPO remained hig...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 1999-06, Vol.42 (6), p.527-536
Hauptverfasser:	Fortineau, Anne-Dominique, Brichory, Franck, Pellen, Pascal, Sai, Catherine, Dazord, Léontine, Mortier, Jacques, Vaultier, Michel, Bourguet, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	autoradiography biodistribution Biological and medical sciences Chemistry Contrast media. Radiopharmaceuticals Exact sciences and technology hepatic cancer Medical sciences metabolic radiotherapy Organic chemistry Organometalloidal and organometallic compounds P derivatives Pharmacology. Drug treatments Preparations and properties Radiation therapy and radiosensitizing agent Treatment with physical agents Treatment. General aspects tri-n-octylphosphine oxide Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The purpose of this study was to analyse the biodistribution of tri‐n‐octyl[32P]phosphine oxide ([32P]TOPO) in rats following intrahepatic arterial injection so as to assess its potential as a radiopharmaceutical for the treatment of hepatic tumours in humans. The retention of [32P]TOPO remained high in liver and decreased rapidly in kidney, bone marrow and blood. The synthesis of [32P]TOPO was performed in a one step procedure from [32P]OCl3 and n‐octyl magnesium chloride in diethyl ether at 0°C. Copyright © 1999 John Wiley & Sons, Ltd.
ISSN:	0362-4803 1099-1344
DOI:	10.1002/(SICI)1099-1344(199906)42:6<527::AID-JLCR214>3.0.CO;2-9