Comparison of the Host Responses to Wild-Type and cpsB Mutant Klebsiella pneumoniae Infections

Previously, we established an intranasal mouse model of Klebsiella pneumoniae infection and validated its utility using a highly virulent wild-type strain and an avirulent capsular polysaccharide mutant. In the present study we compare the host responses to both infections by examining cytokine prod...

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Veröffentlicht in:	Infection and Immunity 2006-09, Vol.74 (9), p.5402-5407
Hauptverfasser:	Lawlor, Matthew S, Handley, Scott A, Miller, Virginia L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - genetics Bacteriology Biological and medical sciences Cytokines - metabolism Fundamental and applied biological sciences. Psychology Host Response and Inflammation Klebsiella Infections - immunology Klebsiella Infections - microbiology Klebsiella Infections - pathology Klebsiella pneumoniae Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Klebsiella pneumoniae - pathogenicity Lung - microbiology Lung - pathology Mice Mice, Inbred C57BL Microbiology Miscellaneous Pneumonia, Bacterial - immunology Pneumonia, Bacterial - microbiology Pneumonia, Bacterial - pathology
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Beschreibung
Zusammenfassung:	Previously, we established an intranasal mouse model of Klebsiella pneumoniae infection and validated its utility using a highly virulent wild-type strain and an avirulent capsular polysaccharide mutant. In the present study we compare the host responses to both infections by examining cytokine production, cellular infiltration, pulmonary histology, and intranasal immunization.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.00244-06