Dihydroxythiophenes Are Novel Potent Inhibitors of Human Immunodeficiency Virus Integrase with a Diketo Acid-Like Pharmacophore

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Veröffentlicht in:	Journal of Virology 2006-07, Vol.80 (14), p.6883-6894
Hauptverfasser:	KEHLENBECK, S, BETZ, U, PEVZNER, V, SCHOHE-LOOP, R, TSUJISHITA, H, WELKER, R, KREUTER, J, RÜBSAMEN-WAIGMANN, H, DITTMER, F, BIRKMANN, A, FAST, B, GÖLLER, A. H, HENNINGER, K, LOWINGER, T, MARRERO, D, PAESSENS, A, PAULSEN, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Binding Sites - drug effects Binding Sites - genetics Biological and medical sciences Cell Line DNA, Complementary - biosynthesis DNA, Complementary - genetics DNA, Viral - biosynthesis DNA, Viral - genetics Drug Resistance, Viral - drug effects Drug Resistance, Viral - genetics Fundamental and applied biological sciences. Psychology HIV Infections - drug therapy HIV Infections - genetics HIV Infections - metabolism HIV Integrase - genetics HIV Integrase - metabolism HIV Integrase Inhibitors - chemistry HIV Integrase Inhibitors - pharmacology HIV Integrase Inhibitors - therapeutic use HIV-1 - genetics HIV-1 - metabolism Human immunodeficiency virus 1 Humans Microbiology Miscellaneous Models, Molecular Molecular Structure Mutation Protein Binding Structure-Activity Relationship Vaccines and Antiviral Agents Vesicular stomatitis Indiana virus - genetics Vesicular stomatitis Indiana virus - metabolism Vesicular stomatitis virus Virology Virus Integration - drug effects Virus Integration - genetics
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Zusammenfassung:	Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology. For an alternate route to JVI .asm.org, visit: JVI
ISSN:	0022-538X 1098-5514
DOI:	10.1128/JVI.00306-06