Formation of Succinic Acid by Klebsiella pneumoniae MCM B-325 Under Aerobic and Anaerobic Conditions

The present study describes the formation of succinic acid by a nonvirulent, highly osmotolerant Klebsiella pneumoniae strain SAP (succinic acid producer), its profile of metabolites, and enzymes of the succinate production pathway. The strain produced succinate along with other metabolites such as...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2006-06, Vol.16 (6), p.870-879
Hauptverfasser:	Thakker, Chandresh (Microbial Science Division, Agharkar Research Institute, Pune, India), Bhosale, Suresh (Microbial Science Division, Agharkar Research Institute, Pune, India), Ranade, Dilip (Microbial Science Division, Agharkar Research Institute, Pune, India), E-mail: drranade@vsnl.com
Format:	Artikel
Sprache:	eng
Schlagworte:	ACIDE SUCCINIQUE ACIDO SUCCINICO anaerobic bacteria Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology KLEBSIELLA PNEUMONIAE METABOLITE METABOLITES METABOLITOS SUCCINIC ACID TCA cycle
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Zusammenfassung:	The present study describes the formation of succinic acid by a nonvirulent, highly osmotolerant Klebsiella pneumoniae strain SAP (succinic acid producer), its profile of metabolites, and enzymes of the succinate production pathway. The strain produced succinate along with other metabolites such as lactate, acetate, and ethanol under aerobic as well as anaerobic growth conditions. The yield of succinate was higher in the presence of MgCO₃ under N₂ atmosphere as compared with that under CO₂ atmosphere. Analysis of intracellular metabolites showed the presence of a smaller PEP pool than that of pyruvate.
ISSN:	1017-7825