New Controlled-Release Ibuprofen Tablets

Tablets containing two different doses of ibuprofen are realized. The first possesses very fast release kinetics, while the second has slow and linear release kinetics. This allows drug to produce a therapeutic effect quickly and to maintain it for a long time with only one administration unit. Such...

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Veröffentlicht in:	Drug development and industrial pharmacy 1999-01, Vol.25 (5), p.671-677
Hauptverfasser:	Palmieri, Giovanni Filippo, Lovato, Debora, Martelli, Sante
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Biological and medical sciences General pharmacology Ibuprofen - administration & dosage Ibuprofen - chemistry Medical sciences Microscopy, Electron, Scanning Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Solubility Tablets
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Beschreibung
Zusammenfassung:	Tablets containing two different doses of ibuprofen are realized. The first possesses very fast release kinetics, while the second has slow and linear release kinetics. This allows drug to produce a therapeutic effect quickly and to maintain it for a long time with only one administration unit. Such tablets are obtained by compression of a mixture of two very different kinds of granulates: an ibuprofen-starch granulate and an ibuprofen-Eudragit RS microsphere granulate. Specific proportions of mixtures of them give the described result after compression at particular tablet hardnesses.
ISSN:	0363-9045 1520-5762
DOI:	10.1081/DDC-100102224