Adaptive Immunity-Dependent Intestinal Hypermotility Contributes to Host Defense against Giardia spp

Humans infected with Giardia exhibit intestinal hypermotility, but the underlying mechanisms and functional significance are uncertain. Here we show in murine models of giardiasis that small-intestinal hypermotility occurs in a delayed fashion relative to peak parasite burden, is dependent on adapti...

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Veröffentlicht in:	Infection and Immunity 2006-04, Vol.74 (4), p.2473-2476
Hauptverfasser:	Andersen, Yolanda S, Gillin, Frances D, Eckmann, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidiarrheals - pharmacology Biological and medical sciences Disease Models, Animal Fundamental and applied biological sciences. Psychology Fungal and Parasitic Infections Gastrointestinal Motility - drug effects Gastrointestinal Motility - immunology Giardia Giardiasis - drug therapy Giardiasis - immunology Giardiasis - parasitology Immunity, Active Loperamide - pharmacology Mice Mice, Inbred C57BL Mice, Knockout Mice, SCID Microbiology Nitric Oxide Synthase Type I - deficiency Nitric Oxide Synthase Type I - genetics
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Beschreibung
Zusammenfassung:	Humans infected with Giardia exhibit intestinal hypermotility, but the underlying mechanisms and functional significance are uncertain. Here we show in murine models of giardiasis that small-intestinal hypermotility occurs in a delayed fashion relative to peak parasite burden, is dependent on adaptive immune defenses, and contributes to giardial clearance.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.74.4.2473-2476.2006