Inhibition and reversal of platelet aggregation by αIIbβ3 antagonists depends on the anticoagulant and flow conditions: differential effects of Abciximab and Lamifiban

Inhibition and reversal of platelet aggregation by αIIbβ3 antagonists depends on the anticoagulant and flow conditions: differential effects of Abciximab and Lamifiban

Summary Shear influences platelet aggregate formation and stability, as well as the inhibitory capacities of antithrombotic drugs. We compared the inhibitory and disaggregating properties of two distinct αIIbβ3 antagonists, Abciximab and Lamifiban, on platelet aggregation induced by adenosine diphos...

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Veröffentlicht in:British journal of haematology 2005-11, Vol.131 (3), p.348-355
Hauptverfasser: Frojmovic, Mony, Labarthe, Benoit, Legrand, Chantal
Format: Artikel
Sprache:eng
Schlagworte:
aggregation
Biological and medical sciences
Hematologic and hematopoietic diseases
Medical sciences
platelet
shear
αIIbβ3 antagonists
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Zusammenfassung:Summary Shear influences platelet aggregate formation and stability, as well as the inhibitory capacities of antithrombotic drugs. We compared the inhibitory and disaggregating properties of two distinct αIIbβ3 antagonists, Abciximab and Lamifiban, on platelet aggregation induced by adenosine diphosphate (ADP) (5 μmol/l) in platelet‐rich plasma (PRP), in an aggregometer (poorly defined low shear,
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2005.05782.x