A Placebo-Controlled Experimental Study of Steroid Inhalation Therapy in Ammonia-Induced Lung Injury

Background: The use of corticosteroids in toxic lung injury caused by exposure to an irritating gas such its ammonia has not been adequately studied. Objective: To evaluate the effects of budesonide inhalation in a rabbit model of toxic lung injury induced by ammonia. Design: Randomized, blind place...

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Veröffentlicht in:Journal of toxicology. Clinical toxicology 1999, Vol.37 (1), p.59-67
Hauptverfasser: Sjöblom, Eva, Höjer, Jonas, Kulling, Per E J, Stauffer, Kim, Suneson, Annika, Ludwigs, Ulf
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Sprache:eng
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Zusammenfassung:Background: The use of corticosteroids in toxic lung injury caused by exposure to an irritating gas such its ammonia has not been adequately studied. Objective: To evaluate the effects of budesonide inhalation in a rabbit model of toxic lung injury induced by ammonia. Design: Randomized, blind placebo-controlled laboratory investigation employing 16 New Zealand White rabbits. Lung injury was induced by inhalation of a defined amount of aerosolized ammonia. Thirty minutes later, the rabbits were randomized to receive either inhalation therapy with 0.5 mg budesonide or placebo. After another 2 hours, a second treatment inhalation, identical to the first one, was administered. Results: Airway pressures, hemodynamics, and gas exchange were measured at baseline, 5, and 15 minutes after ammonia administration and every 30 minutes during a 6-hour period after the first blind inhalation of corticosteroids or placebo. The ammonia inhalation resulted in an acute severe lung injury, detected after 15 minutes its a decrease in Pao2 from 23.3 (±3.6) to 11.0 (±3.6) kPa (p < 0.005) and an increase in peak airway pressure from 13 (±2) to 17 (±2) cm H2O (p
ISSN:0731-3810
1097-9875
DOI:10.1081/CLT-100102409