Screening and Biotransformation of Interleukin-1β Converting Enzyme Production Inhibitors from Arctii fructus

Five dibenzylbutyrolactones were isolated from a methanol extract of Arctii fructus (Arctium lappa L.) by bioassay-guided isolation, using the interleukin-1β converting enzyme (caspase-1, ICE) production inhibitory assay in vitro. These compounds were spectroscopically identified as lappaol E (1), l...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2005-04, Vol.15 (2), p.269-273
Hauptverfasser:	Kim, H.A. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), Yoon, D.Y. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), Lee, S.M. (KTnG Central Research Institute, Daejeon, Republic of Korea), Baek, S.H. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), Han, G.H. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), Kho, Y.H. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), Lee, C.H. (Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea), E-mail: chlee@kribb.re.kr
Format:	Artikel
Sprache:	eng
Schlagworte:	Arctii fructus Biological and medical sciences Biotechnology D10S cells Fundamental and applied biological sciences. Psychology interleukin-1beta converting enzyme INTERLEUKINE INTERLEUKINS INTERLEUQUINAS
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Zusammenfassung:	Five dibenzylbutyrolactones were isolated from a methanol extract of Arctii fructus (Arctium lappa L.) by bioassay-guided isolation, using the interleukin-1β converting enzyme (caspase-1, ICE) production inhibitory assay in vitro. These compounds were spectroscopically identified as lappaol E (1), lappaol A (2), matairesinol (3), arctigenin (4), and arctiin (5). Among the compounds tested, arctigenin (4) showed the strongest inhibitory activity for ICE production in IL-1β-induced proliferation of D10S cells.
ISSN:	1017-7825