Characteristic spectral studies and in vitro Antimicrobial and in vivo multi-infection antifungal activities in mice of new organotin(IV) derivatives of heterocyclic amino acids

The nature of the products obtained on reacting R3SnCl (R = Me, Bu and Ph), Ph2SnCl2 and Bu2SnO with amino acids having nitrogen‐containing heterocyclic rings; i.e. L‐histidine and DL‐tryptophan, is shown to depend upon the reaction conditions. Ten new organotin(IV) derivatives of these amino acids have been synthesized and characterized by elemental analyses, molar conductance and electronic spectra, and the bonding in these complexes is discussed in terms of their infrared, far‐infrared, 1H and 13C NMR, and 119Sn Mössbauer spectra. The complexes soluble in DMSO have been tested in vitro against a wide spectrum of bacteria and fungi and found to be active. Two complexes, Ph3SnL‐1 and Ph3SnL‐2, have been found to be slightly active in vivo against a multi‐infection fungal model in mice. Copyright © 1999 John Wiley & Sons, Ltd.