Structure-activity relationship for FR901464: A versatile method for the conversion and preparation of biologically active biotinylated probes

The structure-activity relationship for FR901464, a potent cell-cycle inhibitor, was examined by synthesizing its analogs. A versatile method for converting FR901464 was devised. This method made it possible to synthesize biologically active FR901464-biotin conjugates which could be used to isolate...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2004-10, Vol.68 (10), p.2178-2182
Hauptverfasser:	Motoyoshi, H. (Tokyo Univ. (Japan)), Horigome, M, Ishigami, K, Yoshida, T, Horinouchi, S, Yoshida, M, Watanabe, H, Kitahara, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences BIOTIN Biotin - chemistry Biotinylation CELL CYCLE Cell Cycle - drug effects cell cycle inhibitor CHEMICAL SYNTHESIS CHEMICALS conversion FR901464 Fundamental and applied biological sciences. Psychology INHIBITION Pyrans - analysis Pyrans - chemical synthesis Pyrans - chemistry Pyrans - pharmacology Spiro Compounds - analysis Spiro Compounds - chemical synthesis Spiro Compounds - chemistry Spiro Compounds - pharmacology Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	The structure-activity relationship for FR901464, a potent cell-cycle inhibitor, was examined by synthesizing its analogs. A versatile method for converting FR901464 was devised. This method made it possible to synthesize biologically active FR901464-biotin conjugates which could be used to isolate the binding proteins.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.68.2178