THE HERBAL PRESCRIPTION YOUKONGDAN MODULATES RODENT MEMORY, ISCHEMIC DAMAGE AND CORTICAL mRNA GENE EXPRESSION
The effects of the herbal prescription youkongdan (YKD) on memory performance of rodents following cerebral ischemia/reperfusion and scopolamine administration were measured and compared to the age-related changes in mRNA expression induced by dietary supplementation of YKD. Following ischemia, YKD...
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| Veröffentlicht in: | International journal of neuroscience 2004-10, Vol.114 (10), p.1365-1388 |
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| container_title | International journal of neuroscience |
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| creator | SHIN, JOON SHIK SO, CHANG SOK KIM, YOUNG OCK AHN, DUK KYUN SHARMAN, KAIZHI G. SHARMAN, EDWARD H. |
| description | The effects of the herbal prescription youkongdan (YKD) on memory performance of rodents following cerebral ischemia/reperfusion and scopolamine administration were measured and compared to the age-related changes in mRNA expression induced by dietary supplementation of YKD. Following ischemia, YKD decreased neuronal cell loss in the CA1 region of rat hippocampus by 89% relative to controls. YKD improved the water maze performance of both ischemic and scopolamine-treated animals. Dietary administration of YKD resulted in significant modulation of Egr1, Grp78, Hsp86, SOD1, and αB crystallin mRNA expression and a trend toward increased exploratory behavior in older mice. |
| doi_str_mv | 10.1080/00207450490489107 |
| format | Article |
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Following ischemia, YKD decreased neuronal cell loss in the CA1 region of rat hippocampus by 89% relative to controls. YKD improved the water maze performance of both ischemic and scopolamine-treated animals. Dietary administration of YKD resulted in significant modulation of Egr1, Grp78, Hsp86, SOD1, and αB crystallin mRNA expression and a trend toward increased exploratory behavior in older mice.</description><identifier>ISSN: 0020-7454</identifier><identifier>EISSN: 1563-5279</identifier><identifier>EISSN: 1543-5245</identifier><identifier>DOI: 10.1080/00207450490489107</identifier><identifier>PMID: 15370193</identifier><identifier>CODEN: IJNUB7</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Age Factors ; Animal ; Animal ethology ; Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Brain Ischemia - prevention & control ; Cell Count - methods ; Cerebral Cortex - drug effects ; Dietary Supplements ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Drug Interactions ; Early Growth Response Protein 1 ; Exploratory Behavior - drug effects ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - drug effects ; Heat-Shock Proteins - genetics ; Heat-Shock Proteins - metabolism ; Hippocampus - drug effects ; Hippocampus - pathology ; Immediate-Early Proteins - genetics ; Immediate-Early Proteins - metabolism ; Learning. Memory ; Male ; Mammalia ; Maze Learning - drug effects ; Memory ; Memory - drug effects ; Mice ; Mice, Inbred Strains ; Mitogen-Activated Protein Kinase Kinases - genetics ; Mitogen-Activated Protein Kinase Kinases - metabolism ; Molecular Chaperones - genetics ; Molecular Chaperones - metabolism ; Motor Activity - drug effects ; Muscarinic Antagonists - therapeutic use ; Oligonucleotide Array Sequence Analysis - methods ; Phytotherapy - methods ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Preparations - pharmacology ; Plant Preparations - therapeutic use ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Wistar ; Reaction Time - drug effects ; RNA, Messenger - metabolism ; Scopolamine Hydrobromide - therapeutic use ; Superoxide Dismutase - genetics ; Superoxide Dismutase - metabolism ; Superoxide Dismutase-1 ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Vertebrata</subject><ispartof>International journal of neuroscience, 2004-10, Vol.114 (10), p.1365-1388</ispartof><rights>2004 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2004</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-e55ae2c88d388c1aeb5021cf4a9041d75d9a2fdfbc7adeb5d4d1b95d505931403</citedby><cites>FETCH-LOGICAL-c432t-e55ae2c88d388c1aeb5021cf4a9041d75d9a2fdfbc7adeb5d4d1b95d505931403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00207450490489107$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00207450490489107$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16077379$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15370193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHIN, JOON SHIK</creatorcontrib><creatorcontrib>SO, CHANG SOK</creatorcontrib><creatorcontrib>KIM, YOUNG OCK</creatorcontrib><creatorcontrib>AHN, DUK KYUN</creatorcontrib><creatorcontrib>SHARMAN, KAIZHI G.</creatorcontrib><creatorcontrib>SHARMAN, EDWARD H.</creatorcontrib><title>THE HERBAL PRESCRIPTION YOUKONGDAN MODULATES RODENT MEMORY, ISCHEMIC DAMAGE AND CORTICAL mRNA GENE EXPRESSION</title><title>International journal of neuroscience</title><addtitle>Int J Neurosci</addtitle><description>The effects of the herbal prescription youkongdan (YKD) on memory performance of rodents following cerebral ischemia/reperfusion and scopolamine administration were measured and compared to the age-related changes in mRNA expression induced by dietary supplementation of YKD. Following ischemia, YKD decreased neuronal cell loss in the CA1 region of rat hippocampus by 89% relative to controls. YKD improved the water maze performance of both ischemic and scopolamine-treated animals. Dietary administration of YKD resulted in significant modulation of Egr1, Grp78, Hsp86, SOD1, and αB crystallin mRNA expression and a trend toward increased exploratory behavior in older mice.</description><subject>Age Factors</subject><subject>Animal</subject><subject>Animal ethology</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Brain Ischemia - prevention & control</subject><subject>Cell Count - methods</subject><subject>Cerebral Cortex - drug effects</subject><subject>Dietary Supplements</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Drug Interactions</subject><subject>Early Growth Response Protein 1</subject><subject>Exploratory Behavior - drug effects</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Heat-Shock Proteins - genetics</subject><subject>Heat-Shock Proteins - metabolism</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - pathology</subject><subject>Immediate-Early Proteins - genetics</subject><subject>Immediate-Early Proteins - metabolism</subject><subject>Learning. Memory</subject><subject>Male</subject><subject>Mammalia</subject><subject>Maze Learning - drug effects</subject><subject>Memory</subject><subject>Memory - drug effects</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Mitogen-Activated Protein Kinase Kinases - genetics</subject><subject>Mitogen-Activated Protein Kinase Kinases - metabolism</subject><subject>Molecular Chaperones - genetics</subject><subject>Molecular Chaperones - metabolism</subject><subject>Motor Activity - drug effects</subject><subject>Muscarinic Antagonists - therapeutic use</subject><subject>Oligonucleotide Array Sequence Analysis - methods</subject><subject>Phytotherapy - methods</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Preparations - pharmacology</subject><subject>Plant Preparations - therapeutic use</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reaction Time - drug effects</subject><subject>RNA, Messenger - metabolism</subject><subject>Scopolamine Hydrobromide - therapeutic use</subject><subject>Superoxide Dismutase - genetics</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Superoxide Dismutase-1</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Vertebrata</subject><issn>0020-7454</issn><issn>1563-5279</issn><issn>1543-5245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLwzAYhoMoOtQf4EVy8WY1aRrToJfaxq24ttJ1oKeSJi1O2nWkE_Hfm7GJiOApfHzP85LvBeAMoyuMfHSNkIuYR5HHkedzjNgeGGF6QxzqMr4PRpu9YwHvCJwOw6KyM-Hc9f1DcIQpYQhzMgJdMRFwIvL7YAqfcjEL8_ipiLMUvmTzxywdR0EKkyyaT4NCzGCeRSItYCKSLH-5hPEsnIgkDmEUJMFYwCCNYJjlRRzatC5PAzgWqYDieZM8s6kn4KCR7VCf7t5jMH8QRThxptl4IznKI-7aqSmVtat8XxPfV1jWFUUuVo0n7a1YM6q5dBvdVIpJbZfa07jiVFNEOcEeIscAb3OV6YfB1E25MotOms8So3LTXvmnPeucb53Ve9XV-sfYdWWBix0gByXbxsilWgw_3A1ijDBuubstt1g2venkR29aXa7lZ9ubb4n894_bX_prLdv1q5KmLt_6d7O0vf1zxRc9IZM6</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>SHIN, JOON SHIK</creator><creator>SO, CHANG SOK</creator><creator>KIM, YOUNG OCK</creator><creator>AHN, DUK KYUN</creator><creator>SHARMAN, KAIZHI G.</creator><creator>SHARMAN, EDWARD H.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20041001</creationdate><title>THE HERBAL PRESCRIPTION YOUKONGDAN MODULATES RODENT MEMORY, ISCHEMIC DAMAGE AND CORTICAL mRNA GENE EXPRESSION</title><author>SHIN, JOON SHIK ; SO, CHANG SOK ; KIM, YOUNG OCK ; AHN, DUK KYUN ; SHARMAN, KAIZHI G. ; SHARMAN, EDWARD H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-e55ae2c88d388c1aeb5021cf4a9041d75d9a2fdfbc7adeb5d4d1b95d505931403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Age Factors</topic><topic>Animal</topic><topic>Animal ethology</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Brain Ischemia - prevention & control</topic><topic>Cell Count - methods</topic><topic>Cerebral Cortex - drug effects</topic><topic>Dietary Supplements</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Drug Interactions</topic><topic>Early Growth Response Protein 1</topic><topic>Exploratory Behavior - drug effects</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Heat-Shock Proteins - genetics</topic><topic>Heat-Shock Proteins - metabolism</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - pathology</topic><topic>Immediate-Early Proteins - genetics</topic><topic>Immediate-Early Proteins - metabolism</topic><topic>Learning. Memory</topic><topic>Male</topic><topic>Mammalia</topic><topic>Maze Learning - drug effects</topic><topic>Memory</topic><topic>Memory - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Mitogen-Activated Protein Kinase Kinases - genetics</topic><topic>Mitogen-Activated Protein Kinase Kinases - metabolism</topic><topic>Molecular Chaperones - genetics</topic><topic>Molecular Chaperones - metabolism</topic><topic>Motor Activity - drug effects</topic><topic>Muscarinic Antagonists - therapeutic use</topic><topic>Oligonucleotide Array Sequence Analysis - methods</topic><topic>Phytotherapy - methods</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Preparations - pharmacology</topic><topic>Plant Preparations - therapeutic use</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reaction Time - drug effects</topic><topic>RNA, Messenger - metabolism</topic><topic>Scopolamine Hydrobromide - therapeutic use</topic><topic>Superoxide Dismutase - genetics</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Superoxide Dismutase-1</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHIN, JOON SHIK</creatorcontrib><creatorcontrib>SO, CHANG SOK</creatorcontrib><creatorcontrib>KIM, YOUNG OCK</creatorcontrib><creatorcontrib>AHN, DUK KYUN</creatorcontrib><creatorcontrib>SHARMAN, KAIZHI G.</creatorcontrib><creatorcontrib>SHARMAN, EDWARD H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIN, JOON SHIK</au><au>SO, CHANG SOK</au><au>KIM, YOUNG OCK</au><au>AHN, DUK KYUN</au><au>SHARMAN, KAIZHI G.</au><au>SHARMAN, EDWARD H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THE HERBAL PRESCRIPTION YOUKONGDAN MODULATES RODENT MEMORY, ISCHEMIC DAMAGE AND CORTICAL mRNA GENE EXPRESSION</atitle><jtitle>International journal of neuroscience</jtitle><addtitle>Int J Neurosci</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>114</volume><issue>10</issue><spage>1365</spage><epage>1388</epage><pages>1365-1388</pages><issn>0020-7454</issn><eissn>1563-5279</eissn><eissn>1543-5245</eissn><coden>IJNUB7</coden><abstract>The effects of the herbal prescription youkongdan (YKD) on memory performance of rodents following cerebral ischemia/reperfusion and scopolamine administration were measured and compared to the age-related changes in mRNA expression induced by dietary supplementation of YKD. Following ischemia, YKD decreased neuronal cell loss in the CA1 region of rat hippocampus by 89% relative to controls. YKD improved the water maze performance of both ischemic and scopolamine-treated animals. Dietary administration of YKD resulted in significant modulation of Egr1, Grp78, Hsp86, SOD1, and αB crystallin mRNA expression and a trend toward increased exploratory behavior in older mice.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>15370193</pmid><doi>10.1080/00207450490489107</doi><tpages>24</tpages></addata></record> |
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| subjects | Age Factors Animal Animal ethology Animals Behavior, Animal - drug effects Biological and medical sciences Brain Ischemia - prevention & control Cell Count - methods Cerebral Cortex - drug effects Dietary Supplements DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drug Interactions Early Growth Response Protein 1 Exploratory Behavior - drug effects Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Hippocampus - drug effects Hippocampus - pathology Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Learning. Memory Male Mammalia Maze Learning - drug effects Memory Memory - drug effects Mice Mice, Inbred Strains Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Molecular Chaperones - genetics Molecular Chaperones - metabolism Motor Activity - drug effects Muscarinic Antagonists - therapeutic use Oligonucleotide Array Sequence Analysis - methods Phytotherapy - methods Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Preparations - pharmacology Plant Preparations - therapeutic use Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Reaction Time - drug effects RNA, Messenger - metabolism Scopolamine Hydrobromide - therapeutic use Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase-1 Transcription Factors - genetics Transcription Factors - metabolism Vertebrata |
| title | THE HERBAL PRESCRIPTION YOUKONGDAN MODULATES RODENT MEMORY, ISCHEMIC DAMAGE AND CORTICAL mRNA GENE EXPRESSION |
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