THE HERBAL PRESCRIPTION YOUKONGDAN MODULATES RODENT MEMORY, ISCHEMIC DAMAGE AND CORTICAL mRNA GENE EXPRESSION

The effects of the herbal prescription youkongdan (YKD) on memory performance of rodents following cerebral ischemia/reperfusion and scopolamine administration were measured and compared to the age-related changes in mRNA expression induced by dietary supplementation of YKD. Following ischemia, YKD...

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Veröffentlicht in:	International journal of neuroscience 2004-10, Vol.114 (10), p.1365-1388
Hauptverfasser:	SHIN, JOON SHIK, SO, CHANG SOK, KIM, YOUNG OCK, AHN, DUK KYUN, SHARMAN, KAIZHI G., SHARMAN, EDWARD H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animal Animal ethology Animals Behavior, Animal - drug effects Biological and medical sciences Brain Ischemia - prevention & control Cell Count - methods Cerebral Cortex - drug effects Dietary Supplements DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drug Interactions Early Growth Response Protein 1 Exploratory Behavior - drug effects Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Hippocampus - drug effects Hippocampus - pathology Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Learning. Memory Male Mammalia Maze Learning - drug effects Memory Memory - drug effects Mice Mice, Inbred Strains Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Molecular Chaperones - genetics Molecular Chaperones - metabolism Motor Activity - drug effects Muscarinic Antagonists - therapeutic use Oligonucleotide Array Sequence Analysis - methods Phytotherapy - methods Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Preparations - pharmacology Plant Preparations - therapeutic use Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Reaction Time - drug effects RNA, Messenger - metabolism Scopolamine Hydrobromide - therapeutic use Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase-1 Transcription Factors - genetics Transcription Factors - metabolism Vertebrata
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Zusammenfassung:	The effects of the herbal prescription youkongdan (YKD) on memory performance of rodents following cerebral ischemia/reperfusion and scopolamine administration were measured and compared to the age-related changes in mRNA expression induced by dietary supplementation of YKD. Following ischemia, YKD decreased neuronal cell loss in the CA1 region of rat hippocampus by 89% relative to controls. YKD improved the water maze performance of both ischemic and scopolamine-treated animals. Dietary administration of YKD resulted in significant modulation of Egr1, Grp78, Hsp86, SOD1, and αB crystallin mRNA expression and a trend toward increased exploratory behavior in older mice.
ISSN:	0020-7454 1563-5279 1543-5245
DOI:	10.1080/00207450490489107