Application of novel metallocomplexes for mimicking of cytochrome P450: Analysis of product distribution for 1-hexene as a substrate
Graphic While the most catalysts applying for mimicking of oxygenation function of cytochrome P450 rely on the metalloporphyrins, we present here novel approach based on M n+ metallocomplexes of novel ligands: arylmethyl substituted bis-β-aminoketones. The efficacy of catalyst for 1-hexene oxygenati...
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| Veröffentlicht in: | Journal of molecular catalysis. A, Chemical Chemical, 2004-09, Vol.219 (1), p.21-27 |
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| container_title | Journal of molecular catalysis. A, Chemical |
| container_volume | 219 |
| creator | Pulkkinen, Juha Zachar, Pavel Borek, Vojtech Albert Laatikainen, Reino Kral, Vladimir |
| description | Graphic
While the most catalysts applying for mimicking of oxygenation function of cytochrome P450 rely on the metalloporphyrins, we present here novel approach based on M
n+
metallocomplexes of novel ligands: arylmethyl substituted bis-β-aminoketones. The efficacy of catalyst for 1-hexene oxygenation was tested as function of M
n+
, ligand type and reaction conditions. Our results revealed that the best performance is for Co(II) metallocomplexes of ligand
N,
N′-ethylenebis[4-amino-1,5-di-(2-naphthyl)]pent-3-en-2-one are the most efficient for conversion of 1-hexene to oxygenation products. Analysis of product distribution was performed with GC–MS analysis, the mild conditions of analysis allowed to detect primary products of oxygenation reaction. |
| doi_str_mv | 10.1016/j.molcata.2004.04.030 |
| format | Article |
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While the most catalysts applying for mimicking of oxygenation function of cytochrome P450 rely on the metalloporphyrins, we present here novel approach based on M
n+
metallocomplexes of novel ligands: arylmethyl substituted bis-β-aminoketones. The efficacy of catalyst for 1-hexene oxygenation was tested as function of M
n+
, ligand type and reaction conditions. Our results revealed that the best performance is for Co(II) metallocomplexes of ligand
N,
N′-ethylenebis[4-amino-1,5-di-(2-naphthyl)]pent-3-en-2-one are the most efficient for conversion of 1-hexene to oxygenation products. Analysis of product distribution was performed with GC–MS analysis, the mild conditions of analysis allowed to detect primary products of oxygenation reaction.</description><identifier>ISSN: 1381-1169</identifier><identifier>EISSN: 1873-314X</identifier><identifier>DOI: 10.1016/j.molcata.2004.04.030</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Catalysis ; Chemistry ; Cytochrome P450 ; Enzyme mimick ; Exact sciences and technology ; General and physical chemistry ; Metallocomplexes ; Oxygenation ; Product distribution ; Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry</subject><ispartof>Journal of molecular catalysis. A, Chemical, 2004-09, Vol.219 (1), p.21-27</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.molcata.2004.04.030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15954663$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Pulkkinen, Juha</creatorcontrib><creatorcontrib>Zachar, Pavel</creatorcontrib><creatorcontrib>Borek, Vojtech Albert</creatorcontrib><creatorcontrib>Laatikainen, Reino</creatorcontrib><creatorcontrib>Kral, Vladimir</creatorcontrib><title>Application of novel metallocomplexes for mimicking of cytochrome P450: Analysis of product distribution for 1-hexene as a substrate</title><title>Journal of molecular catalysis. A, Chemical</title><description>Graphic
While the most catalysts applying for mimicking of oxygenation function of cytochrome P450 rely on the metalloporphyrins, we present here novel approach based on M
n+
metallocomplexes of novel ligands: arylmethyl substituted bis-β-aminoketones. The efficacy of catalyst for 1-hexene oxygenation was tested as function of M
n+
, ligand type and reaction conditions. Our results revealed that the best performance is for Co(II) metallocomplexes of ligand
N,
N′-ethylenebis[4-amino-1,5-di-(2-naphthyl)]pent-3-en-2-one are the most efficient for conversion of 1-hexene to oxygenation products. Analysis of product distribution was performed with GC–MS analysis, the mild conditions of analysis allowed to detect primary products of oxygenation reaction.</description><subject>Catalysis</subject><subject>Chemistry</subject><subject>Cytochrome P450</subject><subject>Enzyme mimick</subject><subject>Exact sciences and technology</subject><subject>General and physical chemistry</subject><subject>Metallocomplexes</subject><subject>Oxygenation</subject><subject>Product distribution</subject><subject>Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry</subject><issn>1381-1169</issn><issn>1873-314X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNotkE9LxDAQxYsouK5-BCEXj61J0zStF1kW_8GCHhS8hWk6dbOmTUm6i3v3g9u6CwMz8N77MbwoumY0YZTlt5ukdVbDAElKaZZMw-lJNGOF5DFn2efpePOCxYzl5Xl0EcKGjkaesVn0u-h7a8awcR1xDencDi1pcQBrnXZtb_EHA2mcJ61pjf423dfk0_vB6bV3LZK3TNA7sujA7oMJk9h7V2_1QGoTBm-q7T98QrB4PeI6JBAIkLCtRh0GvIzOGrABr457Hn08Prwvn-PV69PLcrGKMeXlEJc5rTATkjZ1yWUhKU2hAMk1pFXRpGUOaVELiShrKQTWKVZySoCkKEQu-Ty6OXB7CBps46HTJqjemxb8XjFRiizP-ei7P_hwfGZn0KugDXYaa-NRD6p2RjGqpvLVRh3LV1P5ahpO-R-fnn1P</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Pulkkinen, Juha</creator><creator>Zachar, Pavel</creator><creator>Borek, Vojtech Albert</creator><creator>Laatikainen, Reino</creator><creator>Kral, Vladimir</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope></search><sort><creationdate>20040901</creationdate><title>Application of novel metallocomplexes for mimicking of cytochrome P450: Analysis of product distribution for 1-hexene as a substrate</title><author>Pulkkinen, Juha ; Zachar, Pavel ; Borek, Vojtech Albert ; Laatikainen, Reino ; Kral, Vladimir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e239t-960be4570fd93787002a8a73ca2b8f296a28d57ee7d755ed2eb70be4a70e55673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Catalysis</topic><topic>Chemistry</topic><topic>Cytochrome P450</topic><topic>Enzyme mimick</topic><topic>Exact sciences and technology</topic><topic>General and physical chemistry</topic><topic>Metallocomplexes</topic><topic>Oxygenation</topic><topic>Product distribution</topic><topic>Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pulkkinen, Juha</creatorcontrib><creatorcontrib>Zachar, Pavel</creatorcontrib><creatorcontrib>Borek, Vojtech Albert</creatorcontrib><creatorcontrib>Laatikainen, Reino</creatorcontrib><creatorcontrib>Kral, Vladimir</creatorcontrib><collection>Pascal-Francis</collection><jtitle>Journal of molecular catalysis. A, Chemical</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pulkkinen, Juha</au><au>Zachar, Pavel</au><au>Borek, Vojtech Albert</au><au>Laatikainen, Reino</au><au>Kral, Vladimir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of novel metallocomplexes for mimicking of cytochrome P450: Analysis of product distribution for 1-hexene as a substrate</atitle><jtitle>Journal of molecular catalysis. A, Chemical</jtitle><date>2004-09-01</date><risdate>2004</risdate><volume>219</volume><issue>1</issue><spage>21</spage><epage>27</epage><pages>21-27</pages><issn>1381-1169</issn><eissn>1873-314X</eissn><abstract>Graphic
While the most catalysts applying for mimicking of oxygenation function of cytochrome P450 rely on the metalloporphyrins, we present here novel approach based on M
n+
metallocomplexes of novel ligands: arylmethyl substituted bis-β-aminoketones. The efficacy of catalyst for 1-hexene oxygenation was tested as function of M
n+
, ligand type and reaction conditions. Our results revealed that the best performance is for Co(II) metallocomplexes of ligand
N,
N′-ethylenebis[4-amino-1,5-di-(2-naphthyl)]pent-3-en-2-one are the most efficient for conversion of 1-hexene to oxygenation products. Analysis of product distribution was performed with GC–MS analysis, the mild conditions of analysis allowed to detect primary products of oxygenation reaction.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><doi>10.1016/j.molcata.2004.04.030</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of molecular catalysis. A, Chemical, 2004-09, Vol.219 (1), p.21-27 |
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| subjects | Catalysis Chemistry Cytochrome P450 Enzyme mimick Exact sciences and technology General and physical chemistry Metallocomplexes Oxygenation Product distribution Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry |
| title | Application of novel metallocomplexes for mimicking of cytochrome P450: Analysis of product distribution for 1-hexene as a substrate |
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