Application of novel metallocomplexes for mimicking of cytochrome P450: Analysis of product distribution for 1-hexene as a substrate

Graphic While the most catalysts applying for mimicking of oxygenation function of cytochrome P450 rely on the metalloporphyrins, we present here novel approach based on M n+ metallocomplexes of novel ligands: arylmethyl substituted bis-β-aminoketones. The efficacy of catalyst for 1-hexene oxygenation was tested as function of M n+ , ligand type and reaction conditions. Our results revealed that the best performance is for Co(II) metallocomplexes of ligand N, N′-ethylenebis[4-amino-1,5-di-(2-naphthyl)]pent-3-en-2-one are the most efficient for conversion of 1-hexene to oxygenation products. Analysis of product distribution was performed with GC–MS analysis, the mild conditions of analysis allowed to detect primary products of oxygenation reaction.