In Vivo Antitumor Activity of Hydrophilic Arginine-Conjugated Linoleic Acid Complex

Although conjugated linoleic acid (CLA) exerted potent antitumor activities in several animal models, application of CLA as a bioactive ingredient has been limited due to its hydrophobicity. This study was designed to determine the antitumor activity of arginine-CLA complex (Arg-CLA), a hydrophilic...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2004-04, Vol.14 (2), p.411-414
Hauptverfasser:	Kim, Y.J. (Korea University, Chochiwon,), Lee, K.W. (Seoul National University, Seoul, Republic of Korea), Kim, D.O. (Cornell University, Geneva, NY, U.S.A.), Kim, T.W. (Cornell University, Ithaca, NY, U.S.A.), Lee, S.K. (Lipozen Inc., Pyoung Taek, Republic of Korea), Lee, H.J. (Seoul National University, Seoul, Republic of Korea), E-mail: leehyjo@snu.ac.kr
Format:	Artikel
Sprache:	eng
Schlagworte:	ACIDE LINOLEIQUE ACIDO LINOLEICO ARGININA ARGININE Biological and medical sciences Biotechnology conjugated linoleic acid forestomach cancer Fundamental and applied biological sciences. Psychology LINOLEIC ACID
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Zusammenfassung:	Although conjugated linoleic acid (CLA) exerted potent antitumor activities in several animal models, application of CLA as a bioactive ingredient has been limited due to its hydrophobicity. This study was designed to determine the antitumor activity of arginine-CLA complex (Arg-CLA), a hydrophilic form of CLA. Mouse forestomach cancer was induced by gavage with benzo(a)pyrene (B(a)p) for 4-weeks prior to Arg-CLA (0.2 and 0.5%) feeding. Complete necropsies were performed to determine the number, size and locations of all the forestomach tumors at 20 weeks post-B(a)P administration.
ISSN:	1017-7825