Urinary Albumin Excretion and its Relationship to C-reactive Protein and Proinflammatory Cytokines in Patients with Cancer and Febrile Neutropenia

The aim of the study was to evaluate urinary albumin excretion (UAE) in cancer patients with neutropenic fever and to correlate UAE with the acute-phase response and secretion of proinflammatory cytokines. UAE and serum values of C-reactive protein (CRP), interleukin-6 (IL-6), and tumour necrosis fa...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Scandinavian journal of infectious diseases 2003, Vol.35 (8), p.491-494
Hauptverfasser: Pedersen, Lars M., Bergmann, Olav J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The aim of the study was to evaluate urinary albumin excretion (UAE) in cancer patients with neutropenic fever and to correlate UAE with the acute-phase response and secretion of proinflammatory cytokines. UAE and serum values of C-reactive protein (CRP), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha) were measured in 32 consecutive cancer patients during episodes of neutropenic fever. UAE increased during fever reaching a peak level 36 h after the onset of fever. CRP, IL-6 and TNF-alpha had peak levels within the first 24 h. UAE correlated significantly with CRP, IL-6 and TNF-alpha. UAE was higher in patients with microbiologically documented infections than in patients with unexplained fever at the time of fever development, whereas UAE was similar in patients with either microbiologically or clinically documented infections. The results suggest a glomerular leakage of albumin secondary to an activated inflammatory response in neutropenic patients with fever. UAE may be a simple and sensitive test in monitoring the acute response to infection in the neutropenic patient.
ISSN:0036-5548
1651-1980
DOI:10.1080/00365540310012415