Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract

To confirm the absorption of proanthocyanidin (PA) into the human body, four healthy adults were ad-ministered 2.0 g of PA-rich grape seed extract (GSE). Blood were drawn before intake and 2 h after intake. Through the enzymatic treatment of sulfatase and v-glucuronidase, blood samples were analyzed...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2003-05, Vol.67 (5), p.1140-1143
Hauptverfasser:	Sano, A. (Kikkoman Corp., Noda, Chiba (Japan)), Yamakoshi, J, Tokutake, S, Tobe, K, Kubota, Y, Kikuchi, M
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption ANTHOCYANIDINS Antioxidants - pharmacokinetics Biflavonoids Biological and medical sciences BLOOD SERUM CATECHIN Catechin - blood Chromatography, High Pressure Liquid Electrochemistry EXTRACTS Fundamental and applied biological sciences. Psychology grape seed extract GRAPES HPLC human HUMAN DISEASES Humans Intestinal Absorption Mass Spectrometry NUTRIENT INTAKE Plant Extracts - chemistry proanthocyanidin Proanthocyanidins - pharmacokinetics procyanidin B1 SEEDS Seeds - chemistry Vitis - chemistry
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Zusammenfassung:	To confirm the absorption of proanthocyanidin (PA) into the human body, four healthy adults were ad-ministered 2.0 g of PA-rich grape seed extract (GSE). Blood were drawn before intake and 2 h after intake. Through the enzymatic treatment of sulfatase and v-glucuronidase, blood samples were analyzed by HPLC coupled with mass-spectrometry (LC/MS). Procyanidin B1 [epicatechin-(4v->8)-catechin] was detected in human serum 2 h after intake. Its concentration was 10.6 =+- 2.5 nmol/l.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.67.1140