Biosynthesis of Vitamin B6 in Yeast. Incorporation Pattern of Trioses

Biosynthesis of Vitamin B6 in Yeast. Incorporation Pattern of Trioses

The biosynthetic origin of the C3 unit, C-6,5,5‘, of pyridoxamine was investigated in two yeasts, Candida utilis ATCC 9256 and Saccharomyces cerevisiae ATCC 7752. The incorporation patterns within pyridoxamine bishydrochloride derived from variously multiply 13C- and 2H-labeled samples of glycerol a...

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Veröffentlicht in:Journal of organic chemistry 2003-05, Vol.68 (9), p.3486-3493
Hauptverfasser: Zeidler, Johannes, Gupta, Ram Nath, Sayer, Brian G., Spenser, Ian D.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Organic chemistry
Preparations and properties
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Zusammenfassung:The biosynthetic origin of the C3 unit, C-6,5,5‘, of pyridoxamine was investigated in two yeasts, Candida utilis ATCC 9256 and Saccharomyces cerevisiae ATCC 7752. The incorporation patterns within pyridoxamine bishydrochloride derived from variously multiply 13C- and 2H-labeled samples of glycerol and glyceraldehyde, established by NMR spectroscopy, indicate that the three-carbon unit C-6,5,5‘ of pyridoxamine is derived intact from a triose.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo020730k