Biotransformation of a Fungicide Ethaboxam by Soil Fungus Cunninghamella elegans

Metabolism of a new fungicide ethaboxam by soil fungi was studied. Among the fungi tested, Cunninghamella elegans produced metabolites from ethabxam, which were not found in the control experiments. M5, a major metaboxam by LC/MS/MS and NMR. N-Deethylated ethaboxam has been found as a single metabol...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2003-02, Vol.13 (1), p.43-49
Hauptverfasser:	Park, M.K, Kim, J.H. (Seoul National University, Suwon, Republic of Korea), Liu, K.H. (Inje University College of medicine, Busan, Republic of Korea), Lim, Y.H. (Konkuk University, Seoul, Republic of Korea), Lee, Y.H. (Kyunghee University, Suwon, Republic of Korea), Hur, H.G. (Kwangju Institute of Science and Technology, Gwangju, Republic ofn Korea)
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology fungicides metabolism Methods. Procedures. Technologies
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Zusammenfassung:	Metabolism of a new fungicide ethaboxam by soil fungi was studied. Among the fungi tested, Cunninghamella elegans produced metabolites from ethabxam, which were not found in the control experiments. M5, a major metaboxam by LC/MS/MS and NMR. N-Deethylated ethaboxam has been found as a single metabolite in in vitro metabolism with rat liver microsomes. M1 was provided to be 4-ethyl-2-(ethylamino)-1,3-thiazole-5-carboxamide by comparing with the authentic compound
ISSN:	1017-7825