Apoptosis induced by the flavonoid from lemon fruit (Citrus limon Burm. f.) and its metabolites in HL-60 cells

The flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites, particularly eriodictyol, 3,4-dihydroxyhydrocinnamic acid, and phloroglucinol had the function of DNA fragmentation in HL-60 cells when analyzed by flow cytometry. An apoptotic DNA ladder and chromatin condensation were obse...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2000-05, Vol.64 (5), p.1075-1078
Hauptverfasser:	Ogata, S. (Mie Univ., Tsu (Japan). Faculty of Bioresources), Miyake, Y, Yamamoto, K, Okumura, K, Taguchi, H
Format:	Artikel
Sprache:	eng
Schlagworte:	APOPTOSE APOPTOSIS Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Caffeic Acids - pharmacology Caspase Inhibitors Cell Size Citrus - chemistry CITRUS LIMON DNA Fragmentation - drug effects Dose-Response Relationship, Drug Electrophoresis, Agar Gel eriodictyol Flavanones FLAVONOIDE FLAVONOIDES FLAVONOIDS Flavonoids - chemistry Flavonoids - metabolism Flavonoids - pharmacology General pharmacology Hesperidin - analogs & derivatives Hesperidin - pharmacology HL-60 HL-60 Cells Humans lemon fruit Medical sciences METABOLITE METABOLITES METABOLITOS Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phloroglucinol - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites, particularly eriodictyol, 3,4-dihydroxyhydrocinnamic acid, and phloroglucinol had the function of DNA fragmentation in HL-60 cells when analyzed by flow cytometry. An apoptotic DNA ladder and chromatin condensation were observed in HL-60 cells when treated with these compounds. The caspase inhibitor prevented DNA fragmentation. These compounds are anticipated to be useful for medical purposes.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.64.1075