A Novel Mechanism for Myocardial Stunning Involving Impaired Ca2+ Handling

The mechanism of myocardial stunning has been studied extensively in rodents and is thought to involve a decrease in Ca responsiveness of the myofilaments, degradation of Troponin I (TnI), and no change in Ca handling. We studied the mechanism of stunning in isolated myocytes from chronically instru...

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Veröffentlicht in:	Circulation research 2001-10, Vol.89 (9), p.831-837
Hauptverfasser:	Kim, Song-Jung, Kudej, Raymond K, Yatani, Atsuko, Kim, Young-Kwon, Takagi, Gen, Honda, Ritsu, Colantonio, David A, Van Eyk, Jennifer E, Vatner, Dorothy E, Rasmusson, Randall L, Vatner, Stephen F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cardiology. Vascular system Coronary heart disease Heart Medical sciences
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Zusammenfassung:	The mechanism of myocardial stunning has been studied extensively in rodents and is thought to involve a decrease in Ca responsiveness of the myofilaments, degradation of Troponin I (TnI), and no change in Ca handling. We studied the mechanism of stunning in isolated myocytes from chronically instrumented pigs. Myocytes were isolated from the ischemic (stunned) and nonischemic (normal) regions after 90-minute coronary stenosis followed by 60-minute reperfusion. Baseline myocyte contraction was reduced, P
ISSN:	0009-7330 1524-4571
DOI:	10.1161/hh2101.098547