Angiotensin II AT1A Receptor Antisense Lowers Blood Pressure in Acute 2-Kidney, 1-Clip Hypertension

Angiotensin II AT1A Receptor Antisense Lowers Blood Pressure in Acute 2-Kidney, 1-Clip Hypertension

To test the effectiveness of antisense oligonucleotides targeted to the angiotensin type 1A (AT1A) receptor mRNA on blood pressure reduction, the 2-kidney, 1-clip (2K1C) Goldblatt model of hypertension was studied in the acute phase of hypertension, when the peripheral renin-angiotensin system is ov...

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Veröffentlicht in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2001-09, Vol.38 (3, Part 2 Suppl), p.674-678
Hauptverfasser: Galli, Sara M, Phillips, M Ian
Format: Artikel
Sprache:eng
Schlagworte:
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Experimental diseases
Medical sciences
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Zusammenfassung:To test the effectiveness of antisense oligonucleotides targeted to the angiotensin type 1A (AT1A) receptor mRNA on blood pressure reduction, the 2-kidney, 1-clip (2K1C) Goldblatt model of hypertension was studied in the acute phase of hypertension, when the peripheral renin-angiotensin system is overactive. A single injection of AT1A receptor antisense oligodeoxynucleotides significantly reduced systolic blood pressure for a period of 8 days in 2K1C rats after clipping, from 157.5±5 mm Hg on day 7 to 141.3±3.0 mm Hg on day 15 after clipping (P
ISSN:0194-911X
1524-4563