ENANTIOSEPARATION ON AMYLOSE TRIS(3,5-DIMETHOXYPHENYL CARBAMATE): APPLICATION TO COMMERCIAL PHARMACEUTICAL CHIRAL DRUGS

The enantioselectivity of the amylose tris(3,5-dimethoxyphenyl carbamate) phase towards some β-blockers was investigated. A sensitive HPLC method was developed for the enantiomers of metoprolol and betaxolol. The validated methods were suitable for the analysis of enantiomeric composition in a varie...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of liquid chromatography & related technologies 1999-01, Vol.22 (20), p.3091-3099
Hauptverfasser:	Cass, Quezia B., Tiritan, M. Elizabeth, Calafatti, Silvana A., Matlin, Stephen A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical chemistry Biological and medical sciences Chemistry Chromatographic methods and physical methods associated with chromatography Exact sciences and technology General pharmacology Medical sciences Other chromatographic methods Pharmacology. Drug treatments
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The enantioselectivity of the amylose tris(3,5-dimethoxyphenyl carbamate) phase towards some β-blockers was investigated. A sensitive HPLC method was developed for the enantiomers of metoprolol and betaxolol. The validated methods were suitable for the analysis of enantiomeric composition in a variety of pharmaceutical formulations of both drugs.
ISSN:	1082-6076 1520-572X
DOI:	10.1081/JLC-100102077