P1783ATG-F(GRAFALON) VS THYMOGLOBULIN(R ATG) AS AN INDUCTION AGENT IN LIVING DONOR RENAL TRANSPLANT -A RETROSPECTIVE SINGLE CENTER EXPERIENCE

Abstract Background and Aims The best modality of renal replacement therapy for patients with end stage renal disease is kidney transplantation. Induction agents play a crucial role in preventing acute rejection which also has bearing on long term graft outcomes. Lymphocyte depleting induction agents commonly used include r ATG (Thymoglobulin), ATG-F (Grafalon) & Alemtuzumab. In this study we compare Grafalon (ATG-F) with r ATG(Thymoglobulin) as induction agent for living donor renal transplant. To study efficacy and safety of ATG-F (Grafalon) as induction agent in comparison to r ATG (Thymoglobulin) in living donor renal transplantation Method This was a single center retrospective study. All the patients who underwent living donor renal transplant at our centre since January 2017 with minimal follow up of 3 months were included. Retransplants & deceased donor transplants were excluded. ATG-F (Grafalon) was given at 6 mg /kg (2 divided doses) & r ATG (Thymoglobulin ) at 3 mg/kg (2 divided doses) doses followed by triple immunosupression (Tacrolimus +MMF +Steroids) . Acute graft dysfunction was defined as a 25% increase in serum creatinine level from baseline. All acute rejection episodes were biopsy proven. Results During the study period 570 living donor renal transplants were done. Patients were followed up for median duration of 22 months (3-35 months). r ATG(Thymoglobulin) was given to 242 (42.4%) patients whereas 78 (13.6%) patients received ATG-F(Grafalon) as induction agent. Mean recipient age was 43±12 years in ATG-F group vs 41±13 yrs in r ATG group (p=0.22) & mean donor age was 48±10 years(ATG-F) vs 47±11 yrs(r ATG) (p=0.48) . Recipients were predominantly male (92 % ,83% p =0.08) while donors were predominantly female (79% ,75% p=0.25) in both the groups. Mean HLA mismatch was 4.1±1.2(ATG-F) vs 4.09±1.3(r ATG) p=0.95. The proportion of ABO and HLA incompatible transplants were comparable in both the groups. Incidence of BPAR was 11.5% vs 4.5 % in ATG-F vs Thymoglobulin group( p = 0.03) Incidence of infection was comparable in both the groups (12.8% vs 14.46%, p=0.86). Two patients in Graflon group had BKV nephropathy while 2 patients in rATG had CMV infection. Mean serum creatinine level at follow up of 22 months (Median) was 1.26±0.35 mg/dl (ATG F ) & 1.18±0.34 mg/dl (r ATG) (p =0.07) .Patient survival(p =1) & graft survival (p=0.24) were comparable in both the groups. One patient lost graft due to drug non compliance in grafalon group while t