Effects of Arginine Residue Introduction upon Interaction and Complexation Behavior of Peptide Ribonucleic Acids (PRNAs) with RNA: Synthesis and Properties of α-Containing Arginine
Abstract A novel nucleic acid model using α-peptide ribonucleic acid (α-PRNA) possessing alternative α- PRNA/arginine sequences, where the arginine residue would be expected to stabilize the complex not only by the conventional hydrogen-bonding interactions between the complementary nucleobase pairs...
Gespeichert in:
| Veröffentlicht in: | Nucleic Acids Symposium Series 2008, Vol.52 (1), p.673-674 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 674 |
|---|---|
| container_issue | 1 |
| container_start_page | 673 |
| container_title | Nucleic Acids Symposium Series |
| container_volume | 52 |
| creator | Wada, Takehiko Sawa, Nobuya Sato, Hirofumi Futaki, Shiroh Inoue, Yoshihisa |
| description | Abstract
A novel nucleic acid model using α-peptide ribonucleic acid (α-PRNA) possessing alternative α- PRNA/arginine sequences, where the arginine residue would be expected to stabilize the complex not only by the conventional hydrogen-bonding interactions between the complementary nucleobase pairs but also through the electrostatic interactions between positively charged side-chain groups and RNA's phosphate anions on the backbone. These α-PRNA form stable sequencespecific complex with the complementary RNA. |
| doi_str_mv | 10.1093/nass/nrn340 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_TOX</sourceid><recordid>TN_cdi_oup_primary_10_1093_nass_nrn340</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/nass/nrn340</oup_id><sourcerecordid>733741965</sourcerecordid><originalsourceid>FETCH-LOGICAL-o156t-729f6d4ca8566c693a15c1e13f02c3ecd230bd137a4c810167c15cb68c02d0ff3</originalsourceid><addsrcrecordid>eNpFkc1OGzEUha2qCCJgxb7yqoXFgD2esWe6CxGUSBGNaLseOfYd4mpiD7aHn8diwWv0mXASCl7Y1vGnc498EDqi5JSSmp1ZGcKZ9ZYV5BMaUVHwrMpF_hmNSM5pxijne-gwhL8krYIQUYtdtEcrIXhZ1iP0ctG2oGLArsVjf2ussYBvIBg9AJ7a6J0eVDTO4qFPW1LAy60grcYTt-o7eJQb4RyW8t44v_aaQx-NTlZm4eygOjAKj5XRAR_Pb67H4QQ_mLjE6fod_3qycZlGho3l3LsefDSwyfTvOZs4G-U62O17wgO008ouwOHbuY_-XF78nlxls58_ppPxLHO05DETed1yXShZlZwrXjNJS0WBspbkioHSOSMLTZmQhaoooVyoBCx4pUiuSduyffRt69t7dzdAiM3KBAVdJy24ITSCMVHQmpeJ_PJGDosV6Kb3ZiX9U_P_pxPwdQu4of94Jc26xWbdYrNtkb0C9cGRjA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733741965</pqid></control><display><type>article</type><title>Effects of Arginine Residue Introduction upon Interaction and Complexation Behavior of Peptide Ribonucleic Acids (PRNAs) with RNA: Synthesis and Properties of α-Containing Arginine</title><source>Oxford Journals Open Access Collection</source><creator>Wada, Takehiko ; Sawa, Nobuya ; Sato, Hirofumi ; Futaki, Shiroh ; Inoue, Yoshihisa</creator><creatorcontrib>Wada, Takehiko ; Sawa, Nobuya ; Sato, Hirofumi ; Futaki, Shiroh ; Inoue, Yoshihisa</creatorcontrib><description>Abstract
A novel nucleic acid model using α-peptide ribonucleic acid (α-PRNA) possessing alternative α- PRNA/arginine sequences, where the arginine residue would be expected to stabilize the complex not only by the conventional hydrogen-bonding interactions between the complementary nucleobase pairs but also through the electrostatic interactions between positively charged side-chain groups and RNA's phosphate anions on the backbone. These α-PRNA form stable sequencespecific complex with the complementary RNA.</description><identifier>ISSN: 0261-3166</identifier><identifier>EISSN: 1746-8272</identifier><identifier>DOI: 10.1093/nass/nrn340</identifier><identifier>PMID: 18776559</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Arginine - chemistry ; Borates - chemistry ; Circular Dichroism ; DNA - chemistry ; Nucleic Acid Denaturation ; Nucleic Acid Hybridization ; Oligonucleotides - chemistry ; Peptides - chemistry ; RNA - chemical synthesis ; RNA - chemistry</subject><ispartof>Nucleic Acids Symposium Series, 2008, Vol.52 (1), p.673-674</ispartof><rights>2008 Oxford University Press 2008</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1599,4010,27904,27905,27906</link.rule.ids><linktorsrc>$$Uhttps://dx.doi.org/10.1093/nass/nrn340$$EView_record_in_Oxford_University_Press$$FView_record_in_$$GOxford_University_Press</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18776559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wada, Takehiko</creatorcontrib><creatorcontrib>Sawa, Nobuya</creatorcontrib><creatorcontrib>Sato, Hirofumi</creatorcontrib><creatorcontrib>Futaki, Shiroh</creatorcontrib><creatorcontrib>Inoue, Yoshihisa</creatorcontrib><title>Effects of Arginine Residue Introduction upon Interaction and Complexation Behavior of Peptide Ribonucleic Acids (PRNAs) with RNA: Synthesis and Properties of α-Containing Arginine</title><title>Nucleic Acids Symposium Series</title><addtitle>Nucleic Acids Symp Ser (Oxf)</addtitle><description>Abstract
A novel nucleic acid model using α-peptide ribonucleic acid (α-PRNA) possessing alternative α- PRNA/arginine sequences, where the arginine residue would be expected to stabilize the complex not only by the conventional hydrogen-bonding interactions between the complementary nucleobase pairs but also through the electrostatic interactions between positively charged side-chain groups and RNA's phosphate anions on the backbone. These α-PRNA form stable sequencespecific complex with the complementary RNA.</description><subject>Arginine - chemistry</subject><subject>Borates - chemistry</subject><subject>Circular Dichroism</subject><subject>DNA - chemistry</subject><subject>Nucleic Acid Denaturation</subject><subject>Nucleic Acid Hybridization</subject><subject>Oligonucleotides - chemistry</subject><subject>Peptides - chemistry</subject><subject>RNA - chemical synthesis</subject><subject>RNA - chemistry</subject><issn>0261-3166</issn><issn>1746-8272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1OGzEUha2qCCJgxb7yqoXFgD2esWe6CxGUSBGNaLseOfYd4mpiD7aHn8diwWv0mXASCl7Y1vGnc498EDqi5JSSmp1ZGcKZ9ZYV5BMaUVHwrMpF_hmNSM5pxijne-gwhL8krYIQUYtdtEcrIXhZ1iP0ctG2oGLArsVjf2ussYBvIBg9AJ7a6J0eVDTO4qFPW1LAy60grcYTt-o7eJQb4RyW8t44v_aaQx-NTlZm4eygOjAKj5XRAR_Pb67H4QQ_mLjE6fod_3qycZlGho3l3LsefDSwyfTvOZs4G-U62O17wgO008ouwOHbuY_-XF78nlxls58_ppPxLHO05DETed1yXShZlZwrXjNJS0WBspbkioHSOSMLTZmQhaoooVyoBCx4pUiuSduyffRt69t7dzdAiM3KBAVdJy24ITSCMVHQmpeJ_PJGDosV6Kb3ZiX9U_P_pxPwdQu4of94Jc26xWbdYrNtkb0C9cGRjA</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Wada, Takehiko</creator><creator>Sawa, Nobuya</creator><creator>Sato, Hirofumi</creator><creator>Futaki, Shiroh</creator><creator>Inoue, Yoshihisa</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Effects of Arginine Residue Introduction upon Interaction and Complexation Behavior of Peptide Ribonucleic Acids (PRNAs) with RNA: Synthesis and Properties of α-Containing Arginine</title><author>Wada, Takehiko ; Sawa, Nobuya ; Sato, Hirofumi ; Futaki, Shiroh ; Inoue, Yoshihisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-o156t-729f6d4ca8566c693a15c1e13f02c3ecd230bd137a4c810167c15cb68c02d0ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Arginine - chemistry</topic><topic>Borates - chemistry</topic><topic>Circular Dichroism</topic><topic>DNA - chemistry</topic><topic>Nucleic Acid Denaturation</topic><topic>Nucleic Acid Hybridization</topic><topic>Oligonucleotides - chemistry</topic><topic>Peptides - chemistry</topic><topic>RNA - chemical synthesis</topic><topic>RNA - chemistry</topic><toplevel>online_resources</toplevel><creatorcontrib>Wada, Takehiko</creatorcontrib><creatorcontrib>Sawa, Nobuya</creatorcontrib><creatorcontrib>Sato, Hirofumi</creatorcontrib><creatorcontrib>Futaki, Shiroh</creatorcontrib><creatorcontrib>Inoue, Yoshihisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nucleic Acids Symposium Series</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Wada, Takehiko</au><au>Sawa, Nobuya</au><au>Sato, Hirofumi</au><au>Futaki, Shiroh</au><au>Inoue, Yoshihisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Arginine Residue Introduction upon Interaction and Complexation Behavior of Peptide Ribonucleic Acids (PRNAs) with RNA: Synthesis and Properties of α-Containing Arginine</atitle><jtitle>Nucleic Acids Symposium Series</jtitle><addtitle>Nucleic Acids Symp Ser (Oxf)</addtitle><date>2008</date><risdate>2008</risdate><volume>52</volume><issue>1</issue><spage>673</spage><epage>674</epage><pages>673-674</pages><issn>0261-3166</issn><eissn>1746-8272</eissn><abstract>Abstract
A novel nucleic acid model using α-peptide ribonucleic acid (α-PRNA) possessing alternative α- PRNA/arginine sequences, where the arginine residue would be expected to stabilize the complex not only by the conventional hydrogen-bonding interactions between the complementary nucleobase pairs but also through the electrostatic interactions between positively charged side-chain groups and RNA's phosphate anions on the backbone. These α-PRNA form stable sequencespecific complex with the complementary RNA.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>18776559</pmid><doi>10.1093/nass/nrn340</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 0261-3166 |
| ispartof | Nucleic Acids Symposium Series, 2008, Vol.52 (1), p.673-674 |
| issn | 0261-3166 1746-8272 |
| language | eng |
| recordid | cdi_oup_primary_10_1093_nass_nrn340 |
| source | Oxford Journals Open Access Collection |
| subjects | Arginine - chemistry Borates - chemistry Circular Dichroism DNA - chemistry Nucleic Acid Denaturation Nucleic Acid Hybridization Oligonucleotides - chemistry Peptides - chemistry RNA - chemical synthesis RNA - chemistry |
| title | Effects of Arginine Residue Introduction upon Interaction and Complexation Behavior of Peptide Ribonucleic Acids (PRNAs) with RNA: Synthesis and Properties of α-Containing Arginine |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T13%3A55%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_TOX&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Arginine%20Residue%20Introduction%20upon%20Interaction%20and%20Complexation%20Behavior%20of%20Peptide%20Ribonucleic%20Acids%20(PRNAs)%20with%20RNA:%20Synthesis%20and%20Properties%20of%20%CE%B1-Containing%20Arginine&rft.jtitle=Nucleic%20Acids%20Symposium%20Series&rft.au=Wada,%20Takehiko&rft.date=2008&rft.volume=52&rft.issue=1&rft.spage=673&rft.epage=674&rft.pages=673-674&rft.issn=0261-3166&rft.eissn=1746-8272&rft_id=info:doi/10.1093/nass/nrn340&rft_dat=%3Cproquest_TOX%3E733741965%3C/proquest_TOX%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733741965&rft_id=info:pmid/18776559&rft_oup_id=10.1093/nass/nrn340&rfr_iscdi=true |