Synthesis of oligonucleotides containing the oxidatively modified κB site: unique binding affinity to the NFκB p50 homodimer

Synthesis of oligonucleotide 26-mers including single 5-formyl-2′-deoxy-uridine (1) or 5-formyl-2′-O-methyl-uridine (2) in place of thymidine at the κB site has been accomplished. One of the 26-mers with 1 was critically discriminated by the NFκB p50 homodimer in binding.

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Bibliographische Detailangaben
Veröffentlicht in:	Nucleic Acids Symposium Series 1999-11, Vol.42 (1), p.33-34
Hauptverfasser:	Kittaka, Atsushi, Takayama, Hiroaki, Horii, Chikafumi, Kuze, Tetsuya, Tanaka, Hiromichi, Nakamura, Kazuo T., Miyasaka, Tadashi, Inoue, Jun-ichiro
Format:	Artikel
Sprache:	eng
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Beschreibung
Zusammenfassung:	Synthesis of oligonucleotide 26-mers including single 5-formyl-2′-deoxy-uridine (1) or 5-formyl-2′-O-methyl-uridine (2) in place of thymidine at the κB site has been accomplished. One of the 26-mers with 1 was critically discriminated by the NFκB p50 homodimer in binding.
ISSN:	0261-3166 1746-8272
DOI:	10.1093/nass/42.1.33