1531PDETECTION OF HEALTH-RELATED WARNING SIGNALS THROUGH DAILY TELEMONITORING OF CANCER PATIENTS ON MULTIDRUG CHEMOTHERAPY AT HOME (EUROPEAN PROJECT INCASA)

Abstract Aim: Chemotherapy can be safely administered at home through chronomodulated delivery over the 24 hours via a programmable pump, with improved tolerability and efficacy (Lévi F, Annu Rev Pharm Toxicol 2010). The purpose of the study was to further increment safety through the detection of early warning signals predicting for hospitalization through daily telemonitoring of multidimensional objective and subjective data. Methods: Telemonitoring involved daily self-assessment of body weight, symptoms (M.D. Anderson Symptom Inventory, MDASI), and recording of circadian rest-activity rhythm through a wrist accelerometer (AMI). Data were received in a server, and visualized daily by the medical/nursing staff using a web app. Alarm thresholds were adjusted according to body weight loss, weighted MDASI symptoms according to sparse linear discriminant analysis SLDA, and dichotomy index I