1523PCLINICAL AND LABORATORY PROGNOSTIC FACTORS OF TOXICITY OF BREAST CANCER CHEMOTHERAPY

Abstract Aim: Modern chemotherapy (CT) regimens in patients with breast cancer allow reaching high treatment efficacy. The intensification of CT leads to the elevation of toxicity levels, which cause decrease of intensity of CT. This could reduce the level of response rate. The prognosis of toxicity will help to prevent and treat in proper time CT complication and thus to preserve the treatment efficacy. Methods: 146 patients with breast cancer, received 4-6 cycles of CT with FAC regimen. The complex of clinical, laboratory and instrumental investigations was performed to the patients from this group. The main evaluated toxicity types were hematological, gastrointestinal (GIT), liver and cardiovascular toxicity (CVT). Results: GIT was more common in patients aged less than 50 years old (100% vs 66% in patients older 50 years old, р