Functional complaints and quality of life after transanal total mesorectal excision: a meta-analysis

Abstract Background Total mesorectal excision (TME) gives excellent oncological results in rectal cancer treatment, but patients may experience functional problems. A novel approach to performing TME is by single-port transanal minimally invasive surgery. This systematic review evaluated the functional outcomes and quality of life after transanal and laparoscopic TME. Methods A comprehensive search in PubMed, the Cochrane Library, Embase and the trial registers was conducted in May 2019. PRISMA guidelines were used. Data for meta-analysis were pooled using a random-effects model. Results A total of 11 660 studies were identified, from which 14 studies and six conference abstracts involving 846 patients (599 transanal TME, 247 laparoscopic TME) were included. A substantial number of patients experienced functional problems consistent with low anterior resection syndrome (LARS). Meta-analysis found no significant difference in major LARS between the two approaches (risk ratio 1·13, 95 per cent c.i. 0·94 to 1·35; P = 0·18). However, major heterogeneity was present in the studies together with poor reporting of functional baseline assessment. Conclusion No differences in function were observed between transanal and laparoscopic TME. Graphical abstract A novel surgical technique for total mesorectal excision (TME) is single-port transanal minimally invasive surgery. This systematic review aimed to evaluate the functional outcomes and quality of life after transanal total mesorectal excision (TaTME) and compare them with those of laparoscopic TME (LapTME). No differences between TaTME and LapTME were seen in terms of impaired functioning and reduced quality of life after rectal cancer surgery. However, major heterogeneity was present in the studies together with poor reporting of functional baseline assessment. Graphical Abstract Comparable function