In vitro and in vivo responses of rat tissues to cadmium-induced lipid peroxidation
The in vitro and in vivo responses of rat tissues to cadmium-induced lipid peroxidation (LPO) were documented and compared. The analysis shows that, although the liver has the greatest potential to undergo LPO in vitro, it also has a great capacity to counteract this phenomenon in vivo. The data als...
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| Veröffentlicht in: | Bulletin of environmental contamination and toxicology 1991-06, Vol.46 (6), p.929-936 |
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| container_issue | 6 |
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| container_title | Bulletin of environmental contamination and toxicology |
| container_volume | 46 |
| creator | MANCA, D RICARD, A. C TROTTIER, B CHEVALIER, G |
| description | The in vitro and in vivo responses of rat tissues to cadmium-induced lipid peroxidation (LPO) were documented and compared. The analysis shows that, although the liver has the greatest potential to undergo LPO in vitro, it also has a great capacity to counteract this phenomenon in vivo. The data also suggest that lung and brain could be considered the major target organs to LPO 24 h after exposure to low and moderate doses of Cd as cadmium chloride. These findings are important, when considering that occupational exposure occurs mainly by the inhalation route and that low amounts of Cd can elicit significant oxidative phenomena. |
| doi_str_mv | 10.1007/BF01689740 |
| format | Article |
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These findings are important, when considering that occupational exposure occurs mainly by the inhalation route and that low amounts of Cd can elicit significant oxidative phenomena.</description><identifier>ISSN: 0007-4861</identifier><identifier>EISSN: 1432-0800</identifier><identifier>DOI: 10.1007/BF01689740</identifier><identifier>PMID: 1863802</identifier><identifier>CODEN: BECTA6</identifier><language>eng</language><publisher>New York, NY: Springer-Verlag</publisher><subject>560300 - Chemicals Metabolism & Toxicology ; ANESTHETICS ; Animals ; AZINES ; BARBITURATES ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; Cadmium - pharmacokinetics ; Cadmium - toxicity ; CADMIUM CHLORIDES ; CADMIUM COMPOUNDS ; CADMIUM HALIDES ; CENTRAL NERVOUS SYSTEM DEPRESSANTS ; Chemical and industrial products toxicology. Toxic occupational diseases ; CHEMICAL REACTIONS ; CHLORIDES ; CHLORINE COMPOUNDS ; DRUGS ; ESTERS ; HALIDES ; HALOGEN COMPOUNDS ; HETEROCYCLIC COMPOUNDS ; HYPNOTICS AND SEDATIVES ; IN VITRO ; IN VIVO ; Lipid Peroxidation - drug effects ; LIPIDS ; Male ; Medical sciences ; Metals and various inorganic compounds ; ORGANIC COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; ORGANIC OXYGEN COMPOUNDS ; ORGANIC PHOSPHORUS COMPOUNDS ; OXIDATION ; Oxidation-Reduction ; PHOSPHOLIPIDS ; PYRIMIDINES ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. 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C</creatorcontrib><creatorcontrib>TROTTIER, B</creatorcontrib><creatorcontrib>CHEVALIER, G</creatorcontrib><title>In vitro and in vivo responses of rat tissues to cadmium-induced lipid peroxidation</title><title>Bulletin of environmental contamination and toxicology</title><addtitle>Bull Environ Contam Toxicol</addtitle><description>The in vitro and in vivo responses of rat tissues to cadmium-induced lipid peroxidation (LPO) were documented and compared. The analysis shows that, although the liver has the greatest potential to undergo LPO in vitro, it also has a great capacity to counteract this phenomenon in vivo. The data also suggest that lung and brain could be considered the major target organs to LPO 24 h after exposure to low and moderate doses of Cd as cadmium chloride. These findings are important, when considering that occupational exposure occurs mainly by the inhalation route and that low amounts of Cd can elicit significant oxidative phenomena.</description><subject>560300 - Chemicals Metabolism & Toxicology</subject><subject>ANESTHETICS</subject><subject>Animals</subject><subject>AZINES</subject><subject>BARBITURATES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>Cadmium - pharmacokinetics</subject><subject>Cadmium - toxicity</subject><subject>CADMIUM CHLORIDES</subject><subject>CADMIUM COMPOUNDS</subject><subject>CADMIUM HALIDES</subject><subject>CENTRAL NERVOUS SYSTEM DEPRESSANTS</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>CHEMICAL REACTIONS</subject><subject>CHLORIDES</subject><subject>CHLORINE COMPOUNDS</subject><subject>DRUGS</subject><subject>ESTERS</subject><subject>HALIDES</subject><subject>HALOGEN COMPOUNDS</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HYPNOTICS AND SEDATIVES</subject><subject>IN VITRO</subject><subject>IN VIVO</subject><subject>Lipid Peroxidation - drug effects</subject><subject>LIPIDS</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>ORGANIC OXYGEN COMPOUNDS</subject><subject>ORGANIC PHOSPHORUS COMPOUNDS</subject><subject>OXIDATION</subject><subject>Oxidation-Reduction</subject><subject>PHOSPHOLIPIDS</subject><subject>PYRIMIDINES</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>Rats</subject><subject>Toxicology</subject><issn>0007-4861</issn><issn>1432-0800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFLxDAQRoMo67p68S4EQW_VSZo26VEXVxcWPKjnkiYpRtqkJumi_97KLnj0NHy8x_DNIHRO4IYA8Nv7FZBSVJzBAZoTltMMBMAhmsNEMyZKcoxOYvwAIIWgdIZmRJS5ADpHL2uHtzYFj6XT2P6GrcfBxMG7aCL2LQ4y4WRjHKeYPFZS93bsM-v0qIzGnR2sxoMJ_stqmax3p-iolV00Z_u5QG-rh9flU7Z5flwv7zaZpwxSxlXOCk5MWUEj2qYFwokwFFqpi1YwwTnLoRCKTaUNZ1yAaFqmja4qTTQn-QJd7vb6mGwdlU1GvSvvnFGp5pQLXtFJut5JQ_Cf0wmp7m1UpuukM36MNSkZr_KC_y8yKqbCbBIv9uLY9EbXQ7C9DN_1_qcTv9pzGZXs2iCdsvFPq3jJRJXnP-fsgxQ</recordid><startdate>199106</startdate><enddate>199106</enddate><creator>MANCA, D</creator><creator>RICARD, A. 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C ; TROTTIER, B ; CHEVALIER, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-o240t-7c34571e690b8fbf01718e20fad5f8487743058c4158e747808bf4ded99d1d713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>560300 - Chemicals Metabolism & Toxicology</topic><topic>ANESTHETICS</topic><topic>Animals</topic><topic>AZINES</topic><topic>BARBITURATES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>Cadmium - pharmacokinetics</topic><topic>Cadmium - toxicity</topic><topic>CADMIUM CHLORIDES</topic><topic>CADMIUM COMPOUNDS</topic><topic>CADMIUM HALIDES</topic><topic>CENTRAL NERVOUS SYSTEM DEPRESSANTS</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>CHEMICAL REACTIONS</topic><topic>CHLORIDES</topic><topic>CHLORINE COMPOUNDS</topic><topic>DRUGS</topic><topic>ESTERS</topic><topic>HALIDES</topic><topic>HALOGEN COMPOUNDS</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HYPNOTICS AND SEDATIVES</topic><topic>IN VITRO</topic><topic>IN VIVO</topic><topic>Lipid Peroxidation - drug effects</topic><topic>LIPIDS</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>ORGANIC OXYGEN COMPOUNDS</topic><topic>ORGANIC PHOSPHORUS COMPOUNDS</topic><topic>OXIDATION</topic><topic>Oxidation-Reduction</topic><topic>PHOSPHOLIPIDS</topic><topic>PYRIMIDINES</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>Rats</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MANCA, D</creatorcontrib><creatorcontrib>RICARD, A. C</creatorcontrib><creatorcontrib>TROTTIER, B</creatorcontrib><creatorcontrib>CHEVALIER, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>OSTI.GOV</collection><jtitle>Bulletin of environmental contamination and toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MANCA, D</au><au>RICARD, A. C</au><au>TROTTIER, B</au><au>CHEVALIER, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro and in vivo responses of rat tissues to cadmium-induced lipid peroxidation</atitle><jtitle>Bulletin of environmental contamination and toxicology</jtitle><addtitle>Bull Environ Contam Toxicol</addtitle><date>1991-06</date><risdate>1991</risdate><volume>46</volume><issue>6</issue><spage>929</spage><epage>936</epage><pages>929-936</pages><issn>0007-4861</issn><eissn>1432-0800</eissn><coden>BECTA6</coden><abstract>The in vitro and in vivo responses of rat tissues to cadmium-induced lipid peroxidation (LPO) were documented and compared. The analysis shows that, although the liver has the greatest potential to undergo LPO in vitro, it also has a great capacity to counteract this phenomenon in vivo. The data also suggest that lung and brain could be considered the major target organs to LPO 24 h after exposure to low and moderate doses of Cd as cadmium chloride. These findings are important, when considering that occupational exposure occurs mainly by the inhalation route and that low amounts of Cd can elicit significant oxidative phenomena.</abstract><cop>New York, NY</cop><pub>Springer-Verlag</pub><pmid>1863802</pmid><doi>10.1007/BF01689740</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4861 |
| ispartof | Bulletin of environmental contamination and toxicology, 1991-06, Vol.46 (6), p.929-936 |
| issn | 0007-4861 1432-0800 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 560300 - Chemicals Metabolism & Toxicology ANESTHETICS Animals AZINES BARBITURATES Biological and medical sciences BIOLOGICAL EFFECTS Cadmium - pharmacokinetics Cadmium - toxicity CADMIUM CHLORIDES CADMIUM COMPOUNDS CADMIUM HALIDES CENTRAL NERVOUS SYSTEM DEPRESSANTS Chemical and industrial products toxicology. Toxic occupational diseases CHEMICAL REACTIONS CHLORIDES CHLORINE COMPOUNDS DRUGS ESTERS HALIDES HALOGEN COMPOUNDS HETEROCYCLIC COMPOUNDS HYPNOTICS AND SEDATIVES IN VITRO IN VIVO Lipid Peroxidation - drug effects LIPIDS Male Medical sciences Metals and various inorganic compounds ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANIC OXYGEN COMPOUNDS ORGANIC PHOSPHORUS COMPOUNDS OXIDATION Oxidation-Reduction PHOSPHOLIPIDS PYRIMIDINES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Rats Toxicology |
| title | In vitro and in vivo responses of rat tissues to cadmium-induced lipid peroxidation |
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