Altered Biodistribution of Gallium-67 in a Patient with Aluminum Toxicity Treated with Desferoxamine

Markedly altered biodistribution of [67Ga]citrate was observed in a 66-yr-old hemodialysis patient imaged at 48 hr postinjection. A review of the patient's hospital records revealed toxic serum levels of aluminum, treated with the chelating agent desferoxamine. Based on what is known about the...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 1990-01, Vol.31 (1), p.115-117
Hauptverfasser:	Brown, Steven J, Slizofski, Walter J, Dadparvar, Simin
Format:	Artikel
Sprache:	eng
Schlagworte:	550601 - Medicine- Unsealed Radionuclides in Diagnostics Aged ALUMINIUM Aluminum - adverse effects BETA DECAY RADIOISOTOPES BIOCHEMICAL REACTION KINETICS Biological and medical sciences BODY CARBOXYLIC ACID SALTS CHELATING AGENTS CITRATES Citrates - pharmacokinetics Citric Acid COUNTING TECHNIQUES DATA COVARIANCES DAYS LIVING RADIOISOTOPES Deferoxamine - therapeutic use DIAGNOSTIC TECHNIQUES DIALYSIS DISTRIBUTION Drug Interactions ELECTRON CAPTURE RADIOISOTOPES ELEMENTS GALLIUM 67 GALLIUM ISOTOPES Gallium Radioisotopes Humans INTERMEDIATE MASS NUCLEI Investigative techniques, diagnostic techniques (general aspects) ISOTOPES Kidney Failure, Chronic - therapy KIDNEYS KINETICS Male Medical sciences METALS Miscellaneous. Technology NUCLEI ODD-EVEN NUCLEI ORGANS PATIENTS RADIOISOTOPE SCANNING RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE Radionuclide investigations REACTION KINETICS Renal Dialysis SCINTISCANNING SEPARATION PROCESSES TISSUE DISTRIBUTION
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Zusammenfassung:	Markedly altered biodistribution of [67Ga]citrate was observed in a 66-yr-old hemodialysis patient imaged at 48 hr postinjection. A review of the patient's hospital records revealed toxic serum levels of aluminum, treated with the chelating agent desferoxamine. Based on what is known about the biologic interactions between gallium, aluminum, transferrin, and desferoxamine, we believe that both toxic serum aluminum levels and desferoxamine therapy may cause altered biodistribution on [67Ga]citrate scintigraphy.
ISSN:	0161-5505 1535-5667