Conformational characterization of a single-site mutant of murine epidermal growth factor (EGF) by sup 1 H NMR provides evidence that leucine-47 is involved in the interactions with the EGF receptor

Epidermal growth factor (EGF) is a small protein containing 53 amino acids and three disulfide bonds. There is significant current interest in structure-function relationships in EGF and EGF-like proteins, including the homologous type-{alpha} transforming growth factors. The Leu-47 residue of murin...

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