Late results of combined iodine-125 and external beam radiotherapy in carcinoma of prostate

A total of 96 patients were treated for localized carcinoma of the prostate using combined Iodine-125 (125I) implantation and external beam radiotherapy. The implant was tailored to deliver 10,000 rad to the periphery of the prostate. A significant incidence of serious late rectal complications was...

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Veröffentlicht in:	Urology (Ridgewood, N.J.) N.J.), 1990-07, Vol.36 (1), p.27-30
Hauptverfasser:	PATEL, J, WORTHEN, R, ABADIR, R, WEAVER, D. J, WEINSTEIN, S, ROSS, G. JR
Format:	Artikel
Sprache:	eng
Schlagworte:	ANIMALS BETA DECAY RADIOISOTOPES Biological and medical sciences BODY CARCINOMAS DAYS LIVING RADIOISOTOPES DISEASES ELECTRON CAPTURE RADIOISOTOPES EXTERNAL IRRADIATION Fistula - etiology FISTULAE Follow-Up Studies GLANDS Humans IMPLANTS INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES Iodine Radioisotopes - therapeutic use IRRADIATION ISOTOPES LYMPH NODES Lymphatic Metastasis LYMPHATIC SYSTEM Male MALE GENITALS MAMMALS MAN Medical sciences MEDICINE METASTASES Neoplasm Staging NEOPLASMS Nephrology. Urinary tract diseases NUCLEAR MEDICINE NUCLEI ODD-EVEN NUCLEI ORGANS PATHOLOGICAL CHANGES PATIENTS PRIMATES Proctitis - etiology PROSTATE Prostatic Diseases - etiology Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Prostatic Neoplasms - radiotherapy Radiation Injuries RADIATION SOURCE IMPLANTS RADIATION SOURCES RADIOISOTOPES RADIOLOGY RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy - methods Rectal Fistula - etiology Recurrence SURVIVAL CURVES Survival Rate THERAPY Tumors of the urinary system Urinary Incontinence - etiology Urinary tract. Prostate gland VERTEBRATES 550603 > Medicine-- External Radiation in Therapy-- (1980-)
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Zusammenfassung:	A total of 96 patients were treated for localized carcinoma of the prostate using combined Iodine-125 (125I) implantation and external beam radiotherapy. The implant was tailored to deliver 10,000 rad to the periphery of the prostate. A significant incidence of serious late rectal complications was observed. Positive pelvic nodes were found in 28 percent of the patients. Disease-free survival at seven years was 76 percent for those with negative nodes and 46 percent for patients with positive nodes.
ISSN:	0090-4295 1527-9995
DOI:	10.1016/0090-4295(90)80307-9