Characterization of a thromboxane A2/prostaglandin H2 receptor in guinea pig lung membranes using a radioiodinated thromboxane mimetic

Thromboxane A2 (TXA2) and prostaglandin H2 (PGH2) are potent constrictors of airway smooth muscle and may mediate some of the pulmonary effects of leukotrienes. To date, the TXA2/PGH2 receptor in lung has not been well characterized. In this report, we describe the evaluation of the TXA2/PGH2 recept...

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Veröffentlicht in:	Molecular pharmacology 1991-01, Vol.39 (1), p.72-78
Hauptverfasser:	D L Saussy, Jr, D E Mais, G P DubÃ, D E Magee, K A Brune, W L Kurtz, C M Williams
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques ANIMALS AUTONOMIC NERVOUS SYSTEM AGENTS BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES Binding Sites - drug effects BIOCHEMICAL REACTION KINETICS Biological and medical sciences Blood Platelets - drug effects BODY Bridged Bicyclo Compounds - antagonists & inhibitors Bridged Bicyclo Compounds - pharmacology Bridged Bicyclo Compounds, Heterocyclic CELL CONSTITUENTS CELL MEMBRANES Cell receptors Cell structures and functions CHEMICAL COMPOSITION CONTRACTION DAYS LIVING RADIOISOTOPES DRUGS ELECTRON CAPTURE RADIOISOTOPES Fatty Acids, Unsaturated - antagonists & inhibitors Fatty Acids, Unsaturated - pharmacology Fundamental and applied biological sciences. Psychology GUINEA PIGS In Vitro Techniques INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES Iodine Radioisotopes ISOTOPE APPLICATIONS ISOTOPES KINETICS Lung - drug effects Lung - metabolism LUNGS Male MAMMALS MEMBRANE PROTEINS MEMBRANES Miscellaneous Molecular and cellular biology Muscle Contraction - drug effects MUSCLES NUCLEI ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANS PERFUSED ORGANS PROSTAGLANDINS Prostaglandins H - metabolism PROTEINS RADIOISOTOPES REACTION KINETICS RECEPTORS Receptors, Prostaglandin - chemistry Receptors, Prostaglandin - drug effects Receptors, Thromboxane Receptors, Thromboxane A2, Prostaglandin H2 RESPIRATORY SYSTEM RODENTS SYMPATHOMIMETICS Thromboxanes - metabolism TRACER TECHNIQUES VERTEBRATES
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