Concordance between isolated cleft palate in mice and alterations within a region including the gene encoding the (beta)(3) subunit of the type A (gama)-aminobutyric acid receptor

Concordance between isolated cleft palate in mice and alterations within a region including the gene encoding the (beta)(3) subunit of the type A (gama)-aminobutyric acid receptor

Abnormalities in facial development are among the most common and emotionally wrenching birth defects seen in the general population. The genetic origin and expression of cleft palate in mice is examined.

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Bibliographische Detailangaben
Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1993-06, Vol.90 (11), p.5105
Hauptverfasser: Culiat, Cymbeline T, Stubbs, Lisa, Nicholls, Robert D, Montgomery, Clyde S
Format: Artikel
Sprache:eng
Schlagworte:
550400 - Genetics
ANIMALS
BASIC BIOLOGICAL SCIENCES
Birth defects
CONGENITAL MALFORMATIONS
DIGESTIVE SYSTEM
GENES
MALFORMATIONS
MAMMALS
MAPPING
MICE
MOLECULAR STRUCTURE
MUTATIONS
ORAL CAVITY
PATHOLOGICAL CHANGES
RODENTS
TRANSCRIPTION
VERTEBRATES
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Beschreibung
Zusammenfassung:Abnormalities in facial development are among the most common and emotionally wrenching birth defects seen in the general population. The genetic origin and expression of cleft palate in mice is examined.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.90.11.5105