A respiratory tract dosimetry model for air toxics

The development of a physiologically based pharmacokinetic model for the whole body in which inhalation, exhalation, and metabolism in respiratory tract tissues are taken into account is described. As an example of the model's use, the results of several experiments in which rats and humans wer...

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Veröffentlicht in:	Toxicology and industrial health 1990-10, Vol.6 (5), p.171-180
1. Verfasser:	Overton, J H
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Pollutants - analysis AIR POLLUTION ALKYLATED AROMATICS ANIMALS AROMATICS Dose-Response Relationship, Drug DOSE-RESPONSE RELATIONSHIPS Hazardous Substances - pharmacokinetics Humans HYDROCARBONS MAMMALS MAN MATHEMATICAL MODELS METABOLISM Models, Biological ORGANIC COMPOUNDS POLLUTION PRIMATES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS RESPIRATORY SYSTEM Respiratory System - metabolism RODENTS SENSITIVITY SIMULATION STYRENE Styrenes - pharmacokinetics TOXICITY VERTEBRATES 560300 > Chemicals Metabolism & Toxicology
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Beschreibung
Zusammenfassung:	The development of a physiologically based pharmacokinetic model for the whole body in which inhalation, exhalation, and metabolism in respiratory tract tissues are taken into account is described. As an example of the model's use, the results of several experiments in which rats and humans were exposed to styrene were simulated; these results are discussed. The predicted results agree with the empirical data and with the modeling results of others.
ISSN:	0748-2337 1477-0393
DOI:	10.1177/074823379000600513