Evidence for the presence of angiotensin II-type 1 receptors in brain

Angiotensin II receptor subtypes have been localized in brain by using a novel nonpeptide AII-type 1 receptor antagonist to compete with [ 125I]AII binding in an autoradiographic study. These data contrast with results obtained using the AII-type 2 antagonist PD123177. Both receptor subtypes appear...

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Veröffentlicht in:	Brain research bulletin 1990-09, Vol.25 (3), p.397-400
Hauptverfasser:	Wamsley, James K., Herblin, William F., Alburges, Mario E., Hunt, Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques AII-type 1 receptors AII-type 2 receptors ANGIOTENSIN Angiotensin II Angiotensin II - antagonists & inhibitors Angiotensin II - metabolism Angiotensin Receptor Antagonists ANIMALS AUTORADIOGRAPHY AZINES BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL LOCALIZATION BODY BRAIN Brain Chemistry CARDIOVASCULAR AGENTS CENTRAL NERVOUS SYSTEM Central neurotransmission. Neuromudulation. Pathways and receptors DAYS LIVING RADIOISOTOPES DRUGS DUP 753 ELECTRON CAPTURE RADIOISOTOPES Fundamental and applied biological sciences. Psychology GLOBULINS HETEROCYCLIC COMPOUNDS Hypertension Imidazoles INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES Iodine Radioisotopes ISOTOPES Losartan Male MAMMALS MEMBRANE PROTEINS NERVOUS SYSTEM Neuropeptides Nonpeptide antihypertensive NUCLEI ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANS PROTEINS PYRIDINES RADIOISOTOPES RATS Receptor subtypes RECEPTORS Receptors, Angiotensin - chemistry RODENTS Tetrazoles VASOCONSTRICTORS VERTEBRATES Vertebrates: nervous system and sense organs
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Zusammenfassung:	Angiotensin II receptor subtypes have been localized in brain by using a novel nonpeptide AII-type 1 receptor antagonist to compete with [ 125I]AII binding in an autoradiographic study. These data contrast with results obtained using the AII-type 2 antagonist PD123177. Both receptor subtypes appear to exist in the brain, but the type 1 receptor predominates in the small regions of brain where AII binding is highly concentrated. DUP 753 may have a central action involved in its unique antihypertensive effect.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/0361-9230(90)90226-P