Genotoxicity of the fungicide dichlofluanide in seven assays

Seven different endpoints for detection of genotoxicity have been used to demonstrate the DNA-altering properties of Dichlofluanid, a fungicide commonly used in viticulture pest control. Each endpoint (DNA synthesis inhibition test, alkaline viscosimetry, umu-test, alkaline filter elution, FADU-test...

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Veröffentlicht in:	Environmental and molecular mutagenesis 1991-01, Vol.17:1
Hauptverfasser:	Heil, J., Reifferscheid, G., Hellmich, D., Hergenroeder, M., Zahn, R.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	550601 - Medicine- Unsealed Radionuclides in Diagnostics 560300 - Chemicals Metabolism & Toxicology AUTORADIOGRAPHY AZINES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOASSAY BIOLOGICAL EFFECTS CARBON 14 COMPOUNDS CARCINOGENESIS CHLORINATED ALIPHATIC HYDROCARBONS DAYS LIVING RADIOISOTOPES DNA DNA REPLICATION ELECTRON MICROSCOPY FUNGICIDES GENETIC EFFECTS HALOGENATED ALIPHATIC HYDROCARBONS HELA CELLS HETEROCYCLIC COMPOUNDS HYDROGEN COMPOUNDS ISOTOPES LABELLED COMPOUNDS LIGHT NUCLEI MICROSCOPY MUTAGENESIS NUCLEI NUCLEIC ACID REPLICATION NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ODD-ODD NUCLEI ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANIC NITROGEN COMPOUNDS PATHOGENESIS PESTICIDES PHOSPHORUS 32 PHOSPHORUS ISOTOPES PYRIMIDINES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE RIBOSIDES THYMIDINE TRITIUM COMPOUNDS
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Zusammenfassung:	Seven different endpoints for detection of genotoxicity have been used to demonstrate the DNA-altering properties of Dichlofluanid, a fungicide commonly used in viticulture pest control. Each endpoint (DNA synthesis inhibition test, alkaline viscosimetry, umu-test, alkaline filter elution, FADU-test, {sup 32}P-postlabeling, and electron microscopy) shows clear evidence of genotoxicity. These data indicate that application of the fungicide dichlofluanid may be mutagenic and/or carcinogenic for exposed humans.
ISSN:	0893-6692 1098-2280
DOI:	10.1002/em.2850170104