Evaluation of genotoxic effects of the herbicide dicamba using in vivo and in vitro test systems

The genotoxic effects of the herbicide dicamba have been studied by measuring 1) the unwinding rate of liver DNA from intraperitoneally (i.p.) treated rats (fluorimetric assay); 2) DNA repair as unscheduled DNA synthesis (UDS) induced in cultured human peripheral blood lymphocytes (HPBL); and 3) sis...

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Veröffentlicht in:	Environmental and molecular mutagenesis 1990, Vol.15 (3), p.131-135
Hauptverfasser:	Perocco, P., Ancora, G., Rani, P., Valenti, A. M., Mazzullo, M., Colacci, A., Grilli, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	550501 - Metabolism- Tracer Techniques 560300 - Chemicals Metabolism & Toxicology ANIMAL CELLS ANIMALS BASIC BIOLOGICAL SCIENCES Benzoates - pharmacology BENZOIC ACID Biological and medical sciences BIOLOGICAL EFFECTS BIOLOGICAL MATERIALS BIOLOGICAL RECOVERY BIOLOGICAL REPAIR BLOOD BLOOD CELLS BODY BODY FLUIDS CARBOXYLIC ACIDS Cells, Cultured Chemical mutagenesis CHROMOSOMAL ABERRATIONS CONNECTIVE TISSUE CELLS dicamba Dicamba - pharmacology DIGESTIVE SYSTEM DNA Damage DNA REPAIR DNA REPLICATION DNA, Single-Stranded - biosynthesis DNA, Single-Stranded - drug effects Evaluation Studies as Topic genotoxicity GLANDS herbicide HERBICIDES Humans HYDROGEN COMPOUNDS IN VIVO LEUKOCYTES LIVER Liver - drug effects Liver - metabolism LYMPHOCYTES Lymphocytes - drug effects Lymphocytes - metabolism Male MAMMALS MATERIALS Medical sciences METABOLIC ACTIVATION MONOCARBOXYLIC ACIDS MUTATIONS Nucleic Acid Denaturation NUCLEIC ACID REPLICATION ORGANIC ACIDS ORGANIC COMPOUNDS ORGANS PESTICIDES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS Rats, Inbred Strains RECOVERY REPAIR RODENTS Sister Chromatid Exchange - drug effects SISTER CHROMATID EXCHANGES SOMATIC CELLS Toxicology TRITIUM COMPOUNDS unscheduled DNA synthesis VERTEBRATES
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Zusammenfassung:	The genotoxic effects of the herbicide dicamba have been studied by measuring 1) the unwinding rate of liver DNA from intraperitoneally (i.p.) treated rats (fluorimetric assay); 2) DNA repair as unscheduled DNA synthesis (UDS) induced in cultured human peripheral blood lymphocytes (HPBL); and 3) sister chromatid exchanges (SCE) in HPBL. Results show that dicamba is capable of inducing DNA damage since it significantly increases the unwinding rate of rat liver DNA in vivo and also induces UDS in HPBL in vitro in the presence of exogenous metabolic activation (S‐9 mix). Furthermore, dicamba causes a very slight increase in SCE frequency in HPBL in vitro.
ISSN:	0893-6692 1098-2280
DOI:	10.1002/em.2850150303