Imaging of myocardial infarction in dogs and humans using monoclonal antibodies specific for human myosin heavy chains
The use of three different monoclonal antibodies specific for human ventricular myosin heavy chains in the visualization or the location and extent of necrosis in dogs with experimental acute myocardial infarction and in humans is described. Using a classic immunohistochemical method or ex vivo anal...
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| Veröffentlicht in: | Journal of the American College of Cardiology 1991-08, Vol.18 (2), p.473-484 |
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| creator | Léger, Jocelyne Chevalier, Jeanine Larue, Catherine Gautier, Patrick Planchenault, Jacques Aumaître, Elisabeth Messner, Patrick Puech, Paul Saccavini, Jean-Claude Pau, Bernard Léger, Jean J. |
| description | The use of three different monoclonal antibodies specific for human ventricular myosin heavy chains in the visualization or the location and extent of necrosis in dogs with experimental acute myocardial infarction and in humans is described. Using a classic immunohistochemical method or ex vivo analysis of heart slices in dogs with acute myocardial infarction subjected to intravenous injection of unlabeled antimyosin antibodies or antimyosin antibodies labeled with indium-111, it was observed that all antibody fragments specifically reached the targeted necrotic zone |
| doi_str_mv | 10.1016/0735-1097(91)90603-7 |
| format | Article |
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It is concluded that antimyosin antibodies always reached necrotic areas within 2 h. If blood clearance was rapid, in vivo imaging of the necrotic area was possible 2 to 6 h after necrosis, even in humans. In some cases, however, uncontrolled individual variations in the timing required for sufficient blood clearance hampered this rapid in vivo detection of myocardial necrosis.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/0735-1097(91)90603-7</identifier><identifier>PMID: 1856415</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics ; Aged ; AMINO ACIDS ; ANIMALS ; ANTIBODIES ; Antibodies, Monoclonal - pharmacokinetics ; BETA DECAY RADIOISOTOPES ; Biological and medical sciences ; BLOOD-PLASMA CLEARANCE ; BODY ; CARBOXYLIC ACIDS ; CARDIOVASCULAR DISEASES ; CARDIOVASCULAR SYSTEM ; CHELATING AGENTS ; CLEARANCE ; COUNTING TECHNIQUES ; DAYS LIVING RADIOISOTOPES ; DIAGNOSIS ; DIAGNOSTIC TECHNIQUES ; DISEASES ; DOGS ; DRUGS ; DTPA ; ELECTRON CAPTURE RADIOISOTOPES ; Female ; GLOBULINS ; HEART ; Heart - diagnostic imaging ; Humans ; Immunopathology ; INDIUM 111 ; INDIUM ISOTOPES ; Indium Radioisotopes ; INTERMEDIATE MASS NUCLEI ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPE APPLICATIONS ; ISOTOPES ; Male ; MAMMALS ; MAN ; Medical sciences ; MINUTES LIVING RADIOISOTOPES ; MONOCLONAL ANTIBODIES ; MYOCARDIAL INFARCTION ; Myocardial Infarction - diagnostic imaging ; MYOSIN ; Myosins - immunology ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANS ; Pentetic Acid ; PRIMATES ; PROTEINS ; RADIOIMMUNODETECTION ; RADIOIMMUNOSCINTIGRAPHY ; RADIOISOTOPE SCANNING ; RADIOISOTOPES ; RADIOLOGY AND NUCLEAR MEDICINE ; Radionuclide Imaging ; RADIOPROTECTIVE SUBSTANCES ; SCINTISCANNING ; SPECIFICITY ; Time Factors ; TRACER TECHNIQUES ; VERTEBRATES</subject><ispartof>Journal of the American College of Cardiology, 1991-08, Vol.18 (2), p.473-484</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-de5e9c929ed095e7787515ec4e87d08bc0a44fd12e54818fdd0d14d0dba683493</citedby><cites>FETCH-LOGICAL-c447t-de5e9c929ed095e7787515ec4e87d08bc0a44fd12e54818fdd0d14d0dba683493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0735-1097(91)90603-7$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5306701$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1856415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5323919$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Léger, Jocelyne</creatorcontrib><creatorcontrib>Chevalier, Jeanine</creatorcontrib><creatorcontrib>Larue, Catherine</creatorcontrib><creatorcontrib>Gautier, Patrick</creatorcontrib><creatorcontrib>Planchenault, Jacques</creatorcontrib><creatorcontrib>Aumaître, Elisabeth</creatorcontrib><creatorcontrib>Messner, Patrick</creatorcontrib><creatorcontrib>Puech, Paul</creatorcontrib><creatorcontrib>Saccavini, Jean-Claude</creatorcontrib><creatorcontrib>Pau, Bernard</creatorcontrib><creatorcontrib>Léger, Jean J.</creatorcontrib><title>Imaging of myocardial infarction in dogs and humans using monoclonal antibodies specific for human myosin heavy chains</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>The use of three different monoclonal antibodies specific for human ventricular myosin heavy chains in the visualization or the location and extent of necrosis in dogs with experimental acute myocardial infarction and in humans is described. Using a classic immunohistochemical method or ex vivo analysis of heart slices in dogs with acute myocardial infarction subjected to intravenous injection of unlabeled antimyosin antibodies or antimyosin antibodies labeled with indium-111, it was observed that all antibody fragments specifically reached the targeted necrotic zone <2 h after antibody injection and remzaineo bound for up to 24 h. In a limited but significant number of cases (5 of the 12 humans and 11 of 43 dogs), it was possible to image the necrotic zone in vivo as early as 2 to 4 h after antibody injection. In other cases, individual blood clearance variations retarded or even prevented in vivo necrosis detection. Higher antimyosin fixation values were obtained in the necrotic zones in dogs with a rapid blood clearance relative to that of the other dogs.
It is concluded that antimyosin antibodies always reached necrotic areas within 2 h. If blood clearance was rapid, in vivo imaging of the necrotic area was possible 2 to 6 h after necrosis, even in humans. In some cases, however, uncontrolled individual variations in the timing required for sufficient blood clearance hampered this rapid in vivo detection of myocardial necrosis.</description><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics</subject><subject>Aged</subject><subject>AMINO ACIDS</subject><subject>ANIMALS</subject><subject>ANTIBODIES</subject><subject>Antibodies, Monoclonal - pharmacokinetics</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BLOOD-PLASMA CLEARANCE</subject><subject>BODY</subject><subject>CARBOXYLIC ACIDS</subject><subject>CARDIOVASCULAR DISEASES</subject><subject>CARDIOVASCULAR SYSTEM</subject><subject>CHELATING AGENTS</subject><subject>CLEARANCE</subject><subject>COUNTING TECHNIQUES</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DIAGNOSIS</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DISEASES</subject><subject>DOGS</subject><subject>DRUGS</subject><subject>DTPA</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>Female</subject><subject>GLOBULINS</subject><subject>HEART</subject><subject>Heart - diagnostic imaging</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>INDIUM 111</subject><subject>INDIUM ISOTOPES</subject><subject>Indium Radioisotopes</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPE APPLICATIONS</subject><subject>ISOTOPES</subject><subject>Male</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>Medical sciences</subject><subject>MINUTES LIVING RADIOISOTOPES</subject><subject>MONOCLONAL ANTIBODIES</subject><subject>MYOCARDIAL INFARCTION</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>MYOSIN</subject><subject>Myosins - immunology</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANS</subject><subject>Pentetic Acid</subject><subject>PRIMATES</subject><subject>PROTEINS</subject><subject>RADIOIMMUNODETECTION</subject><subject>RADIOIMMUNOSCINTIGRAPHY</subject><subject>RADIOISOTOPE SCANNING</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radionuclide Imaging</subject><subject>RADIOPROTECTIVE SUBSTANCES</subject><subject>SCINTISCANNING</subject><subject>SPECIFICITY</subject><subject>Time Factors</subject><subject>TRACER TECHNIQUES</subject><subject>VERTEBRATES</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEUhYMoYzv6BgpBRHRRmnQllWQzIIM_AwNudB3SNzfdkaqkTaoa-u2tsppx5yYJ3O8ccs8h5CVnHzjj3UemWtlwZtQ7w98b1rG2UY_Ihkupm1Ya9ZhsHpCn5FmtvxhjnebmilxxLTvB5Yac7ga3j2lPc6DDOYMrPrqexhRcgTHmND-pz_tKXfL0MA0uVTrVRTHklKHPacZdGuMu-4iV1iNCDBFoyGXlF99ZQA_oTmcKBxdTfU6eBNdXfHG5r8nPL59_3H5r7r9_vbv9dN-AEGpsPEo0YLYGPTMSldJKcokgUCvP9A6YEyJ4vkUpNNfBe-a5mI-d63QrTHtNXq--uY7RVogjwgFySgijle22NXyB3q7QseTfE9bRDrEC9r1LmKdqNVNMqG47g2IFoeRaCwZ7LHFw5Ww5s0sndgncLoFbw-3fTqyaZa8u_tNuQP9PtJYwz99c5q6C60NxCWJ9wGTLOsX4jN2sGM6BnSKWZR9MgD6WZR2f4___8QdmuqlB</recordid><startdate>19910801</startdate><enddate>19910801</enddate><creator>Léger, Jocelyne</creator><creator>Chevalier, Jeanine</creator><creator>Larue, Catherine</creator><creator>Gautier, Patrick</creator><creator>Planchenault, Jacques</creator><creator>Aumaître, Elisabeth</creator><creator>Messner, Patrick</creator><creator>Puech, Paul</creator><creator>Saccavini, Jean-Claude</creator><creator>Pau, Bernard</creator><creator>Léger, Jean J.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19910801</creationdate><title>Imaging of myocardial infarction in dogs and humans using monoclonal antibodies specific for human myosin heavy chains</title><author>Léger, Jocelyne ; Chevalier, Jeanine ; Larue, Catherine ; Gautier, Patrick ; Planchenault, Jacques ; Aumaître, Elisabeth ; Messner, Patrick ; Puech, Paul ; Saccavini, Jean-Claude ; Pau, Bernard ; Léger, Jean J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-de5e9c929ed095e7787515ec4e87d08bc0a44fd12e54818fdd0d14d0dba683493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>550601 - Medicine- Unsealed Radionuclides in Diagnostics</topic><topic>Aged</topic><topic>AMINO ACIDS</topic><topic>ANIMALS</topic><topic>ANTIBODIES</topic><topic>Antibodies, Monoclonal - pharmacokinetics</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BLOOD-PLASMA CLEARANCE</topic><topic>BODY</topic><topic>CARBOXYLIC ACIDS</topic><topic>CARDIOVASCULAR DISEASES</topic><topic>CARDIOVASCULAR SYSTEM</topic><topic>CHELATING AGENTS</topic><topic>CLEARANCE</topic><topic>COUNTING TECHNIQUES</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DIAGNOSIS</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DISEASES</topic><topic>DOGS</topic><topic>DRUGS</topic><topic>DTPA</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>Female</topic><topic>GLOBULINS</topic><topic>HEART</topic><topic>Heart - diagnostic imaging</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>INDIUM 111</topic><topic>INDIUM ISOTOPES</topic><topic>Indium Radioisotopes</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPE APPLICATIONS</topic><topic>ISOTOPES</topic><topic>Male</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>Medical sciences</topic><topic>MINUTES LIVING RADIOISOTOPES</topic><topic>MONOCLONAL ANTIBODIES</topic><topic>MYOCARDIAL INFARCTION</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>MYOSIN</topic><topic>Myosins - immunology</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANS</topic><topic>Pentetic Acid</topic><topic>PRIMATES</topic><topic>PROTEINS</topic><topic>RADIOIMMUNODETECTION</topic><topic>RADIOIMMUNOSCINTIGRAPHY</topic><topic>RADIOISOTOPE SCANNING</topic><topic>RADIOISOTOPES</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radionuclide Imaging</topic><topic>RADIOPROTECTIVE SUBSTANCES</topic><topic>SCINTISCANNING</topic><topic>SPECIFICITY</topic><topic>Time Factors</topic><topic>TRACER TECHNIQUES</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Léger, Jocelyne</creatorcontrib><creatorcontrib>Chevalier, Jeanine</creatorcontrib><creatorcontrib>Larue, Catherine</creatorcontrib><creatorcontrib>Gautier, Patrick</creatorcontrib><creatorcontrib>Planchenault, Jacques</creatorcontrib><creatorcontrib>Aumaître, Elisabeth</creatorcontrib><creatorcontrib>Messner, Patrick</creatorcontrib><creatorcontrib>Puech, Paul</creatorcontrib><creatorcontrib>Saccavini, Jean-Claude</creatorcontrib><creatorcontrib>Pau, Bernard</creatorcontrib><creatorcontrib>Léger, Jean J.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Léger, Jocelyne</au><au>Chevalier, Jeanine</au><au>Larue, Catherine</au><au>Gautier, Patrick</au><au>Planchenault, Jacques</au><au>Aumaître, Elisabeth</au><au>Messner, Patrick</au><au>Puech, Paul</au><au>Saccavini, Jean-Claude</au><au>Pau, Bernard</au><au>Léger, Jean J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Imaging of myocardial infarction in dogs and humans using monoclonal antibodies specific for human myosin heavy chains</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>1991-08-01</date><risdate>1991</risdate><volume>18</volume><issue>2</issue><spage>473</spage><epage>484</epage><pages>473-484</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>The use of three different monoclonal antibodies specific for human ventricular myosin heavy chains in the visualization or the location and extent of necrosis in dogs with experimental acute myocardial infarction and in humans is described. Using a classic immunohistochemical method or ex vivo analysis of heart slices in dogs with acute myocardial infarction subjected to intravenous injection of unlabeled antimyosin antibodies or antimyosin antibodies labeled with indium-111, it was observed that all antibody fragments specifically reached the targeted necrotic zone <2 h after antibody injection and remzaineo bound for up to 24 h. In a limited but significant number of cases (5 of the 12 humans and 11 of 43 dogs), it was possible to image the necrotic zone in vivo as early as 2 to 4 h after antibody injection. In other cases, individual blood clearance variations retarded or even prevented in vivo necrosis detection. Higher antimyosin fixation values were obtained in the necrotic zones in dogs with a rapid blood clearance relative to that of the other dogs.
It is concluded that antimyosin antibodies always reached necrotic areas within 2 h. If blood clearance was rapid, in vivo imaging of the necrotic area was possible 2 to 6 h after necrosis, even in humans. In some cases, however, uncontrolled individual variations in the timing required for sufficient blood clearance hampered this rapid in vivo detection of myocardial necrosis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1856415</pmid><doi>10.1016/0735-1097(91)90603-7</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the American College of Cardiology, 1991-08, Vol.18 (2), p.473-484 |
| issn | 0735-1097 1558-3597 |
| language | eng |
| recordid | cdi_osti_scitechconnect_5323919 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | 550601 - Medicine- Unsealed Radionuclides in Diagnostics Aged AMINO ACIDS ANIMALS ANTIBODIES Antibodies, Monoclonal - pharmacokinetics BETA DECAY RADIOISOTOPES Biological and medical sciences BLOOD-PLASMA CLEARANCE BODY CARBOXYLIC ACIDS CARDIOVASCULAR DISEASES CARDIOVASCULAR SYSTEM CHELATING AGENTS CLEARANCE COUNTING TECHNIQUES DAYS LIVING RADIOISOTOPES DIAGNOSIS DIAGNOSTIC TECHNIQUES DISEASES DOGS DRUGS DTPA ELECTRON CAPTURE RADIOISOTOPES Female GLOBULINS HEART Heart - diagnostic imaging Humans Immunopathology INDIUM 111 INDIUM ISOTOPES Indium Radioisotopes INTERMEDIATE MASS NUCLEI ISOMERIC TRANSITION ISOTOPES ISOTOPE APPLICATIONS ISOTOPES Male MAMMALS MAN Medical sciences MINUTES LIVING RADIOISOTOPES MONOCLONAL ANTIBODIES MYOCARDIAL INFARCTION Myocardial Infarction - diagnostic imaging MYOSIN Myosins - immunology NUCLEI ODD-EVEN NUCLEI ORGANIC ACIDS ORGANIC COMPOUNDS ORGANS Pentetic Acid PRIMATES PROTEINS RADIOIMMUNODETECTION RADIOIMMUNOSCINTIGRAPHY RADIOISOTOPE SCANNING RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE Radionuclide Imaging RADIOPROTECTIVE SUBSTANCES SCINTISCANNING SPECIFICITY Time Factors TRACER TECHNIQUES VERTEBRATES |
| title | Imaging of myocardial infarction in dogs and humans using monoclonal antibodies specific for human myosin heavy chains |
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