Imaging of myocardial infarction in dogs and humans using monoclonal antibodies specific for human myosin heavy chains

The use of three different monoclonal antibodies specific for human ventricular myosin heavy chains in the visualization or the location and extent of necrosis in dogs with experimental acute myocardial infarction and in humans is described. Using a classic immunohistochemical method or ex vivo anal...

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Veröffentlicht in:	Journal of the American College of Cardiology 1991-08, Vol.18 (2), p.473-484
Hauptverfasser:	Léger, Jocelyne, Chevalier, Jeanine, Larue, Catherine, Gautier, Patrick, Planchenault, Jacques, Aumaître, Elisabeth, Messner, Patrick, Puech, Paul, Saccavini, Jean-Claude, Pau, Bernard, Léger, Jean J.
Format:	Artikel
Sprache:	eng
Schlagworte:	550601 - Medicine- Unsealed Radionuclides in Diagnostics Aged AMINO ACIDS ANIMALS ANTIBODIES Antibodies, Monoclonal - pharmacokinetics BETA DECAY RADIOISOTOPES Biological and medical sciences BLOOD-PLASMA CLEARANCE BODY CARBOXYLIC ACIDS CARDIOVASCULAR DISEASES CARDIOVASCULAR SYSTEM CHELATING AGENTS CLEARANCE COUNTING TECHNIQUES DAYS LIVING RADIOISOTOPES DIAGNOSIS DIAGNOSTIC TECHNIQUES DISEASES DOGS DRUGS DTPA ELECTRON CAPTURE RADIOISOTOPES Female GLOBULINS HEART Heart - diagnostic imaging Humans Immunopathology INDIUM 111 INDIUM ISOTOPES Indium Radioisotopes INTERMEDIATE MASS NUCLEI ISOMERIC TRANSITION ISOTOPES ISOTOPE APPLICATIONS ISOTOPES Male MAMMALS MAN Medical sciences MINUTES LIVING RADIOISOTOPES MONOCLONAL ANTIBODIES MYOCARDIAL INFARCTION Myocardial Infarction - diagnostic imaging MYOSIN Myosins - immunology NUCLEI ODD-EVEN NUCLEI ORGANIC ACIDS ORGANIC COMPOUNDS ORGANS Pentetic Acid PRIMATES PROTEINS RADIOIMMUNODETECTION RADIOIMMUNOSCINTIGRAPHY RADIOISOTOPE SCANNING RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE Radionuclide Imaging RADIOPROTECTIVE SUBSTANCES SCINTISCANNING SPECIFICITY Time Factors TRACER TECHNIQUES VERTEBRATES
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Zusammenfassung:	The use of three different monoclonal antibodies specific for human ventricular myosin heavy chains in the visualization or the location and extent of necrosis in dogs with experimental acute myocardial infarction and in humans is described. Using a classic immunohistochemical method or ex vivo analysis of heart slices in dogs with acute myocardial infarction subjected to intravenous injection of unlabeled antimyosin antibodies or antimyosin antibodies labeled with indium-111, it was observed that all antibody fragments specifically reached the targeted necrotic zone
ISSN:	0735-1097 1558-3597
DOI:	10.1016/0735-1097(91)90603-7