DNA strand break metabolism in human lymphocytes: A reevaluation

DNA strand break metabolism in human lymphocytes: A reevaluation

Recent findings concerning the presumed existence of single-strand breaks (SSB) in quiescent human peripheral blood lymphocytes (PBL) are discussed in relation to the role of poly(ADP-ribosyl)ation in DNA strand break metabolism. It is argued that the activation of poly(ADP-ribose)polymerase (ADPRP)...

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Veröffentlicht in:Experimental cell research 1991-09, Vol.196 (1), p.1-5
1. Verfasser: Boerrigter, Michael E.T.I.
Format: Artikel
Sprache:eng
Schlagworte:
560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
Biological and medical sciences
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL PATHWAYS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DNA
DNA Damage
DNA POLYMERASES
DNA REPAIR
DNA, Single-Stranded - metabolism
ELECTROMAGNETIC RADIATION
ENZYMES
Fundamental and applied biological sciences. Psychology
Humans
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
Lymphocytes - metabolism
MAMMALS
MAN
MATERIALS
Molecular and cellular biology
MOLECULAR BIOLOGY
Molecular genetics
NUCLEIC ACIDS
NUCLEOTIDYLTRANSFERASES
ORGANIC COMPOUNDS
PHOSPHORUS-GROUP TRANSFERASES
POLYMERASES
PRIMATES
PROTEINS
RADIATION EFFECTS
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RADIATIONS
REPAIR
SOMATIC CELLS
STRAND BREAKS
TRANSFERASES
VERTEBRATES
X RADIATION
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Zusammenfassung:Recent findings concerning the presumed existence of single-strand breaks (SSB) in quiescent human peripheral blood lymphocytes (PBL) are discussed in relation to the role of poly(ADP-ribosyl)ation in DNA strand break metabolism. It is argued that the activation of poly(ADP-ribose)polymerase (ADPRP) by a DNA-damaging agent is not indicative of an obligatory role of poly(ADP-ribosyl)ation in DNA repair. From this it follows that SSB induced by different strand-breaking agents might be removed by either ADPRP-dependent or ADPRP-independent DNA repair pathways.
ISSN:0014-4827
1090-2422
DOI:10.1016/0014-4827(91)90448-4