The Pharmacological Effects of Some Radioprotective Agents in Mice

The Pharmacological Effects of Some Radioprotective Agents in Mice

Methods are described for the measurement and recording of blood pressure, gut activity, and respiration in the mouse. Responses to some antiradiation compounds are presented. Differences in reaction to some radioprotectant thiuronium compounds after intravenous administration in mice and cats are d...

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Veröffentlicht in:Radiation research 1962-11, Vol.17 (5), p.792-800
Hauptverfasser: DiStefano, Victor, Klahn, Janet J., Leary, Daniel E.
Format: Artikel
Sprache:eng
Schlagworte:
Administered dose
Animals
Automatic picture transmission
BIOCHEMISTRY
BLOOD CIRCULATION
Blood pressure
BLOOD VESSELS
Bromides
Dosage
HYPERTENSION
Intraperitoneal injections
Intravenous injections
LUNGS
MEASURED VALUES
MICE
Old Medline
ORGANIC COMPOUNDS
Pharmacology
PHYSIOLOGY
PRESSURE
RADIATION PROTECTION
Radiation-Protective Agents
RADIOLOGY AND NUCLEAR MEDICINE
Respiration
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Beschreibung
Zusammenfassung:Methods are described for the measurement and recording of blood pressure, gut activity, and respiration in the mouse. Responses to some antiradiation compounds are presented. Differences in reaction to some radioprotectant thiuronium compounds after intravenous administration in mice and cats are described, The irtraperitoneal administration of four radioprotectant compounds to mice gave rise to a persistent hypertension. The significance of this finding is discussed.
ISSN:0033-7587
1938-5404
DOI:10.2307/3571227